{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:23Z","timestamp":1791389903860,"version":"4.3.3"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2019,7,30]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Objective:<\/jats:title>\n                    <jats:p>Fatigue is a common debilitating symptom in Parkinson\u2019s disease (PD) of unclear etiology. Hypotension and blood pressure variability are common in PD though their relationship to other non-motor symptoms is less well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study to explore differences in 24-hour ambulatory blood pressure measurements in PD subjects ( n\u200a=\u200a35) with and without fatigue. Subjects underwent hourly systolic (SBP) and diastolic (DBP) blood pressure testing in their home environment. The presence of fatigue was assessed using the Movement Disorders Society Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS) part 1. We compared blood pressure measurements in fatigued vs. non-fatigued PD subjects, assessed over 4 epochs: overnight, morning, midday, and evening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PD subjects with symptoms of fatigue demonstrated lower mean DBP, compared to those without fatigue (67.8\u00b14.8 mmHg vs. 75.6\u00b19.4 t\u200a=\u200a2.57, p\u200a=\u200a0.014). These intergroup differences were most notable in the morning. The two groups did not differ in scoring on the Survey of Autonomic Symptoms or on an office-based blood assessment of SBP or DBP performed on the day of 24-hour monitor initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Fatigue in PD may be a clinical manifestation of low-grade systemic hypotension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-191579","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:22:58Z","timestamp":1559046178000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fatigue in Parkinson\u2019s Disease Associates with Lower Ambulatory Diastolic Blood Pressure"],"prefix":"10.1177","volume":"9","author":[{"given":"Vikas","family":"Kotagal","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Veterans Affairs Ann Arbor Health System (VAAAHS) and GRECC, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Szpara","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Veterans Affairs Ann Arbor Health System (VAAAHS) and GRECC, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Veterans Affairs Ann Arbor Health System (VAAAHS) and GRECC, Ann Arbor, MI, USA"},{"name":"University of Michigan Morris K. Udall Center of Excellence for Parkinson\u2019s Disease Research, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas I.","family":"Bohnen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Veterans Affairs Ann Arbor Health System (VAAAHS) and GRECC, Ann Arbor, MI, USA"},{"name":"University of Michigan Morris K. Udall Center of Excellence for Parkinson\u2019s Disease Research, Ann Arbor, MI, USA"},{"name":"Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,25]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21240"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.02033.x"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26511"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2016"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010925.pub2"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5260"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047387"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq268"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.8.874"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824d587f"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2010000400005"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182120147"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23190"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27233"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.04.023"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1129-x"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23744"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-s262"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.4.noc50340"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003426"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8789-8"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.2.172"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31828bfb7f"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1177\/0891988715598234"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4970"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00049"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816100-00006"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1159\/000489574"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283336ddb"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(13)70024-5"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26718"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25628"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/580683"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31819ccd2a"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000080365.95436.B8"},{"key":"ref038","author":"Krbot Skoric M","year":"2018","journal-title":"Clin Auton Res"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-191579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-191579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-191579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:46:46Z","timestamp":1777610806000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-191579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,25]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7,30]]}},"alternative-id":["10.3233\/JPD-191579"],"URL":"https:\/\/doi.org\/10.3233\/jpd-191579","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,25]]}}}