{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:55:01Z","timestamp":1777888501477,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2019,12,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several scales are available for rating the severity of tremor at present. However, the sensitivity to change of these instruments has remained to be clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the sensitivity of the Fahn-Tolosa-Marin Tremor Rating Scale, the Part III of the Movement Disorder Society-sponsored Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS) and the MDS-UPDRS Tremor Scale to the effects of various antitremor treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Enrolling subjects with parkinsonism associated with tremor, we analyzed two scenarios: (1) tremor changes associated with acute levodopa challenge ( n\u200a=\u200a287) and (2) a 12-month outcome of different treatment options ( n\u200a=\u200a512) including deep brain stimulation ( n\u200a=\u200a146), levodopa\/carbidopa intestinal gel infusion ( n\u200a=\u200a30), and initiating ( n\u200a=\u200a63) or adjusting oral antiparkinsonian medication ( n\u200a=\u200a273). Changes in tremor scales were assessed by effect size values (Cohen\u2019s d and eta-square).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Part B of the Fahn-Tolosa-Marin Tremor Rating Scale was the most sensitive to acute levodopa challenge (Cohen\u2019s d\u200a=\u200a\u20131.04, \u03b7\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a0.12). However, Part A of the Fahn-Tolosa-Marin Tremor Rating Scale showed the highest effect size, which was a small one (Cohen\u2019s d\u200a=\u200a\u20130.33, \u03b7\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a0.03), for detecting a treatment-related change in the severity of tremor during long-term follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The Fahn-Tolosa-Marin Tremor Rating Scale has a better ability to capture changes due to levodopa challenge or antiparkinsonian treatment than MDS-UPDRS Part III or MDS-UPDRS Tremor Scale.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-191800","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:51:09Z","timestamp":1576842669000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Which Scale Best Detects Treatment Response of Tremor in Parkinsonism?"],"prefix":"10.1177","volume":"10","author":[{"given":"D\u00e1vid","family":"Pint\u00e9r","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"Doctoral School of Clinical Neurosciences, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Forjaz","sequence":"additional","affiliation":[{"name":"National School of Public Health, Institute of Health Carlos III and REDISSEC, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Martinez-Martin","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology, Institute of Health Carlos III and CIBERNED, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Rodriguez-Blazquez","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology, Institute of Health Carlos III and CIBERNED, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Ayala","sequence":"additional","affiliation":[{"name":"National School of Public Health, Institute of Health Carlos III and REDISSEC, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annam\u00e1ria","family":"Juh\u00e1sz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"Doctoral School of Clinical Neurosciences, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rk","family":"Harmat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"Doctoral School of Clinical Neurosciences, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Janszky","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"MTA-PTE Clinical Neuroscience MR Research Group, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"MTA-PTE Clinical Neuroscience MR Research Group, P\u00e9cs, 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