{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:38:24Z","timestamp":1793709504093,"version":"4.6.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>Background: Patients with idiopathic Parkinson's disease (PD) or atypical Parkinsonism (AP) often present with orthostatic hypotension (OH) as a result of the dysautonomia associated with the disease or as a side effect of the dopaminergic medications used to treat it. Our recent study suggested that OH negatively impacts gross motor, balance, and cognitive functions in patients with PD. Objective: To determine if correcting the orthostatic hypotension (OH) of patients with PD or AP improves their gross motor, balance, and cognitive functions. Methods: Forty patients with PD or AP were assessed before and after correcting their OH using a staged approach with a goal of SBP &gt;80 when standing and SBP &lt;180 when laying. Step 1 of treatment included reducing antihypertensive medications, as possible, maintaining hydration with 1500cc\/day, decreasing dietary salt, wearing high compression stockings, and keeping the head of bed elevated at 30 degrees when supine. If SBP &lt;80 with standing after step 1, then treatment was started with fludrocortisone and\/or midodrine. Results: Patients' OH was managed as part of a rehabilitation program. Tests such as the Motor and Cognitive Functional Independence Measures, Berg Balance Scale, Two Minute Walking test, and the Finger Tapping test showed significant improvements (p &lt; 0.05) in their gross motor, walking, balance and cognitive function with our OH management plan. No significant differences between admission and discharge were found in the Timed Up and Go test. Conclusion: Our data suggest that monitoring and correcting the OH of patients with PD or AP improves their gross motor, balance, and cognitive function.<\/jats:p>","DOI":"10.3233\/jpd-2012-012101","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:53:47Z","timestamp":1575381227000},"page":"235-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Treating Orthostatic Hypotension in Patients with Parkinson's Disease                     and Atypical Parkinsonism Improves Function"],"prefix":"10.1177","volume":"2","author":[{"given":"Anna D.","family":"Hohler","sequence":"first","affiliation":[{"name":"Department of Neurology, Boston University School of Medicine, Boston,\r                    MA, USA"},{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Elena","family":"Amariei","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University School of Medicine, Boston,\r                    MA, USA"},{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Joy","family":"DePiero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University School of Medicine, Boston,\r                    MA, USA"},{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie B.","family":"Allen","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Boyle","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Alison","family":"Phenix","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara Ashley","family":"DeAngelis","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie Denise","family":"Geibel","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Saint-Hilaire","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University School of Medicine, Boston,\r                    MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Ellis","sequence":"additional","affiliation":[{"name":"Braintree Rehabilitation Hospital, Braintree, MA, USA"},{"name":"Sargent College, Boston University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-2012-012101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-2012-012101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:47:56Z","timestamp":1777610876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-2012-012101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8,1]]}},"alternative-id":["10.3233\/JPD-2012-012101"],"URL":"https:\/\/doi.org\/10.3233\/jpd-2012-012101","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,1]]}}}