{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:14:37Z","timestamp":1792664077061,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>Levodopa-induced dyskinesias (LID) belong to the most common dose-limiting adverse effects of levodopa therapy. \u201cPeak-dose\u201d LID occur with the maximum effect of medication, \u2018diphasic dyskinesias\u2019 have a \u201cbeginning- and end-of-dose\u201d pattern, and the, \u201coff-period dyskinesia\u201d occur during off-periods, most frequently in the early mornings and are typically dystonic in nature. The majority of patients will have developed dyskinesias after 10 years of treatment, and about 40\u201350% after 5 years. Occurrence of LID appears to be related to dose and duration of treatment with levodopa and severity and duration of disease. In addition, patients with younger age of onset have been reported to have an earlier onset and higher rate of LID. The important aetiological role of non-physiological pulsatile stimulation of dopaminergic receptors is increasingly recognized and more continuous dopaminergic stimulation with the longer acting dopamine agonists has been shown to reduce and delay the onset of dyskinesias. LID may not have a significant effect on quality of life in patients with early disease or in very advanced disease stages. when often other problems arise, but in other patients they may be severely disabling. Treatment strategies to overcome LID include adjustment of timing, type and amount of dopaminergic medication, treatment with amantadine and, in treatment resistant cases, stereotactic surgery involving deep brain stimulation or lesioning procedures. A number of other pharmacological options are also being explored. Several methods for the assessment of LID are available to attempt accurate assessment of efficacy, although all of these have limitations, and further evidence on their utility if needed.<\/jats:p>","DOI":"10.3233\/jpd-2012-120103","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:53:58Z","timestamp":1575381238000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":144,"title":["Levodopa-Induced-Dyskinesias Clinical Features, Incidence, Risk                     Factors, Management and Impact on Quality of Life"],"prefix":"10.1177","volume":"2","author":[{"given":"Alice","family":"Manson","sequence":"first","affiliation":[{"name":"Wessex Neurological Centre, Southampton General Hospital, Southampton,\r                    UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Stirpe","sequence":"additional","affiliation":[{"name":"University College London, Institute of Neurology, Royal Free Campus,\r                    London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Schrag","sequence":"additional","affiliation":[{"name":"University College London, Institute of Neurology, Royal Free Campus,\r                    London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-2012-120103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-2012-120103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:48:02Z","timestamp":1777610882000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-2012-120103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8,1]]}},"alternative-id":["10.3233\/JPD-2012-120103"],"URL":"https:\/\/doi.org\/10.3233\/jpd-2012-120103","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fneur.2018.01133","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fneur.2019.01016","asserted-by":"object"}]},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,1]]}}}