{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:44:47Z","timestamp":1782485087741,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2020,9,30]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The impact of concurrent osteoarthritis on mobility and mortality in individuals with Parkinson\u2019s disease is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We sought to understand to what extent osteoarthritis severity influenced mobility across time and how osteoarthritis severity could affect mortality in individuals with Parkinson\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a retrospective observational longitudinal study, data from the Parkinson\u2019s Foundation Quality Improvement Initiative was analyzed. We included 2,274 persons with Parkinson\u2019s disease. The main outcomes were the effects of osteoarthritis severity on functional mobility and mortality. The Timed Up and Go test measured functional mobility performance. Mortality was measured as the osteoarthritis group effect on survival time in years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      More individuals with symptomatic osteoarthritis reported at least monthly falls compared to the other groups (14.5% vs. 7.2% without reported osteoarthritis and 8.4% asymptomatic\/minimal osteoarthritis,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.0004). The symptomatic group contained significantly more individuals with low functional mobility (TUG\u226512 seconds) at baseline (51.5% vs. 29.0% and 36.1%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0001). The odds of having low functional mobility for individuals with symptomatic osteoarthritis was 1.63 times compared to those without reported osteoarthritis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.0004); and was 1.57 times compared to those with asymptomatic\/minimal osteoarthritis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.0026) after controlling pre-specified covariates. Similar results hold at the time of follow-up while changes in functional mobility were not significant across groups, suggesting that osteoarthritis likely does not accelerate the changes in functional mobility across time. Coexisting symptomatic osteoarthritis and Parkinson\u2019s disease seem to additively increase the risk of mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results highlight the impact and potential additive effects of symptomatic osteoarthritis in persons with Parkinson\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-202170","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T10:57:47Z","timestamp":1599562667000},"page":"1601-1610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Coexistent Osteoarthritis and Parkinson\u2019s Disease: Data from the Parkinson\u2019s Foundation Outcomes Project"],"prefix":"10.1177","volume":"10","author":[{"given":"Jaimie A.","family":"Roper","sequence":"first","affiliation":[{"name":"Auburn University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail C.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"University of Florida","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhi","family":"Gao","sequence":"additional","affiliation":[{"name":"University of Florida","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Clarkson University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Florida","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmidt","sequence":"additional","affiliation":[{"name":"East Carolina University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"University of Florida","place":["USA"]},{"name":"Parkinson\u2019s Foundation, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Hass","sequence":"additional","affiliation":[{"name":"University of Florida","place":["USA"]},{"name":"University of Florida","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cubillos","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Foundation, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Parkinson\u2019s Foundation Quality Improvement Initiative Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170047"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01344.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.05.013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/82.9.888"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.11.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21598"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20266"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.03.021"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.06.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(03)00161-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2007.10.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S86001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49115.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.10.016"},{"key":"e_1_3_2_17_2","first-page":"869","article-title":"Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation\u2013United States, 2010\u20132012","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","unstructured":"Centers for Disease Control and Prevention (CDC) (2013) Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation\u2013United States, 2010\u20132012. 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