{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:30:32Z","timestamp":1783002632351,"version":"3.54.5"},"reference-count":82,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2021,4,13]]},"abstract":"<jats:p>Background: Glucagon-like peptide 2 (GLP-2) is a peptide hormone derived from the proglucagon gene expressed in the intestines, pancreas and brain. Some previous studies showed that GLP-2 improved aging and Alzheimer\u2019s disease related memory impairments. Parkinson\u2019s disease (PD) is a progressive neurodegenerative disorder, and to date, there is no particular medicine reversed PD symptoms effectively. Objective: The aim of this study was to evaluate neuroprotective effects of a GLP-2 analogue in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) PD mouse model. Methods: In the present study, the protease resistant Gly(2)-GLP-2 (50\u200anmol\/kg ip.) analogue has been tested for 14 days by behavioral assessment, transmission electron microscope, immunofluorescence histochemistry, enzyme-linked immunosorbent assay and western blot in an acute PD mouse model induced by MPTP. For comparison, the incretin receptor dual agonist DA5-CH was tested in a separate group. Results: The GLP-2 analogue treatment improved the locomotor and exploratory activity of mice, and improved bradykinesia and movement imbalance of mice. Gly(2)-GLP-2 treatment also protected dopaminergic neurons and restored tyrosine hydroxylase expression levels in the substantia nigra. Gly(2)-GLP-2 furthermore reduced the inflammation response as seen in lower microglia activation, and decreased NLRP3 and interleukin-1\u03b2 pro-inflammatory cytokine expression levels. In addition, the GLP-2 analogue improved MPTP-induced mitochondrial dysfunction in the substantia nigra. The protective effects were comparable to those of the dual agonist DA5-CH. Conclusion: The present results demonstrate that Gly(2)-GLP-2 can attenuate NLRP3 inflammasome-mediated inflammation and mitochondrial damage in the substantia nigra induced by MPTP, and Gly(2)-GLP-2 shows neuroprotective effects in this PD animal model.<\/jats:p>","DOI":"10.3233\/jpd-202318","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T12:21:55Z","timestamp":1611922915000},"page":"529-543","source":"Crossref","is-referenced-by-count":16,"title":["Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson\u2019s Disease Mouse Model"],"prefix":"10.1177","volume":"11","author":[{"given":"Zijuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"},{"name":"Basic Medical Collenge, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hao","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"},{"name":"Basic Medical Collenge, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simai","family":"Shao","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical 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Neuroprotective effects of a GIP analogue in the MPTP Parkinson\u2019s disease mouse model","volume":"101","author":"Li","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.3233\/JPD-202318_ref38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbr.2017.03.032","article-title":"A novel dual GLP-1\/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model","volume":"327","author":"Shi","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.3233\/JPD-202318_ref39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3233\/JPD-191768","article-title":"The novel dual GLP-1\/GIP receptor agonist DA-CH5 is superior to single GLP-1 receptor agonists in the MPTP model of Parkinson\u2019s disease","volume":"10","author":"Zhang","year":"2020","journal-title":"J Parkinsons Dis"},{"key":"10.3233\/JPD-202318_ref40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuropharm.2018.01.040","article-title":"Novel dual GLP-1\/GIP receptor agonists show neuroprotective effects in Alzheimer\u2019s and Parkinson\u2019s disease models","volume":"136","author":"H\u00f6lscher","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.3233\/JPD-202318_ref41","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.nbd.2018.10.012","article-title":"Glucagon-like peptide-2 reduces the obesity-associated 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toxicity\u2014a review.","volume":"20","author":"Glover","year":"1986","journal-title":"J Neural Transm Suppl"},{"key":"10.3233\/JPD-202318_ref55","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0304-3940(86)90282-X","article-title":"Histochemistry of MPTP oxidation in the rat brain: Sites of synthesis of the parkinsonism-inducing toxin MPP+","volume":"65","author":"Nakamura","year":"1986","journal-title":"Neurosci Lett"},{"key":"10.3233\/JPD-202318_ref56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0197-0186(87)90024-6","article-title":"The neurotoxicity of 1-methyl-phenyl-1,2,3,6,-tetrahydropyridine (mptp) and its relevance to Parkinson\u2019s disease","volume":"11","author":"Kinemuchi","year":"1987","journal-title":"Neurochem Int"},{"key":"10.3233\/JPD-202318_ref57","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0006-8993(97)00429-0","article-title":"Mitochondrial toxins in models of neurodegenerative diseases. I:} brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methyl-pyridinium or azide ions","volume":"765","author":"Smith","year":"1997","journal-title":"Brain Res"},{"key":"10.3233\/JPD-202318_ref58","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","article-title":"Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain","volume":"4","author":"Cork","year":"2015","journal-title":"Mol Metab"},{"key":"10.3233\/JPD-202318_ref59","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00125-016-3874-y","article-title":"GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: A crossover, randomised, placebo-controlled trial","volume":"59","author":"Farr","year":"2016","journal-title":"Diabetologia"},{"key":"10.3233\/JPD-202318_ref60","doi-asserted-by":"crossref","first-page":"170184","DOI":"10.1016\/j.peptides.2019.170184","article-title":"GIP has neuroprotective effects in Alzheimer and Parkinson\u2019s disease models","volume":"125","author":"Zhang","year":"2020","journal-title":"Peptides"},{"key":"10.3233\/JPD-202318_ref61","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/WNR.0000000000000548","article-title":"A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson\u2019s disease by reducing chronic inflammation in the brain","volume":"27","author":"Cao","year":"2016","journal-title":"Neuroreport"},{"key":"10.3233\/JPD-202318_ref62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2015.09.035","article-title":"A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson\u2019s disease by increasing expression of BNDF","volume":"1634","author":"Ji","year":"2016","journal-title":"Brain Res"},{"key":"10.3233\/JPD-202318_ref63","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2017.06.029","article-title":"A novel GLP-1\/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson\u2019s disease","volume":"812","author":"Yuan","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.3233\/JPD-202318_ref64","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuropharm.2017.02.013","article-title":"A novel GLP-1\/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson\u2019s disease","volume":"117","author":"Jalewa","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.3233\/JPD-202318_ref65","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuropharm.2018.02.012","article-title":"Two novel dual GLP-1\/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson\u2019s disease","volume":"133","author":"Feng","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.3233\/JPD-202318_ref66","doi-asserted-by":"crossref","first-page":"e01505","DOI":"10.1002\/brb3.1505","article-title":"The novel GLP-1\/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. 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