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As they are easily to obtain, they appear a promising tool for the pre-mortem histopathological confirmation of the disease and as a potential outcome measure in studies targeting alpha-synuclein aggregates. Good sensitivity, specificity, and practicability are the most important requirements of a biomarker. The review gives an overview on all three aspects, addresses methodological problems and the lack of standardized procedures as a major problem and gives an outlook on the future of skin biopsy as a potential diagnostic tool in synucleinopathies.<\/jats:p>","DOI":"10.3233\/jpd-202489","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T14:58:49Z","timestamp":1617116329000},"page":"937-947","source":"Crossref","is-referenced-by-count":39,"title":["Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"11","author":[{"given":"Kathrin","family":"Doppler","sequence":"first","affiliation":[{"name":"University Hospital W\u00fcrzburg, Department of Neurology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JPD-202489_ref1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"10.3233\/JPD-202489_ref2","unstructured":"Lewy FH ed. 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