{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:48:20Z","timestamp":1793108900944,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:p>Background: A greater understanding of the everyday experiences of people with Parkinson\u2019s disease (PD) and their carers may help improve clinical practice. Objective: The Parkinson\u2019s Real-world Impact assesSMent (PRISM) study evaluated medication use, health-related quality of life (HRQoL) and the use of healthcare resources by people with PD and their carers. Methods: PRISM is an observational cross-sectional study, in which people with PD and their carers completed an online survey using structured questionnaires, including the Parkinson\u2019s Disease Quality of Life Questionnaire (PDQ-39), Non-Motor Symptoms Questionnaire (NMSQuest) and Zarit Burden Interview (ZBI). Results: Data were collected from 861 people with PD (mean age, 65.0 years; mean disease duration, 7.7 years) and 256 carers from six European countries. People with PD reported a large number of different co-morbidities, non-motor symptoms (mean NMSQuest score, 12.8), and impaired HRQoL (median PDQ-39 summary score, 29.1). Forty-five percent of people with PD reported at least one impulse control behaviour. Treatment patterns varied considerably between different European countries. Levodopa was taken in the last 12 months by 85.9% of participants, and as monotherapy by 21.8%. Carers, who were mostly female (64.8%) and the partner\/spouse of the person with PD (82.1%), reported mild to moderate burden (mean ZBI total score, 26.6). Conclusions: The PRISM study sheds light on the lives of people with PD and those who care for them, re-emphasising the many challenges they face in everyday life. The study also provides insights into the current treatment of PD in Europe.<\/jats:p>","DOI":"10.3233\/jpd-212611","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T13:23:34Z","timestamp":1621603414000},"page":"1309-1323","source":"Crossref","is-referenced-by-count":20,"title":["The Parkinson\u2019s Real-World Impact Assessment (PRISM) Study: A European Survey of the Burden of Parkinson\u2019s Disease in Patients and their Carers"],"prefix":"10.1177","volume":"11","author":[{"given":"Eduardo","family":"Tolosa","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ebersbach","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic, Beelitz-Heilst\u00e4tten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim J.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rascol","sequence":"additional","affiliation":[{"name":"Toulouse Parkinson Expert Center, Departments of Neurosciences and Clinical Pharmacology, Centre d\u2019Investigation Clinique de Toulouse CIC1436, NS-Park\/FCRIN Network, and NeuroToul COEN Center, University Hospital of Toulouse, INSERM, University of Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[{"name":"Parkinson Disease and Movement Disorder Unit, Department of Neurosciences, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Foltynie","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, National Hospital for Neurology and Neurosurgery, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gibson","sequence":"additional","affiliation":[{"name":"The Cure Parkinson\u2019s Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Magalhaes","sequence":"additional","affiliation":[{"name":"BIAL \u2013Portela & C S.A., Coronado, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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