{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:43Z","timestamp":1785326743897,"version":"3.55.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:p>Background: Olfactory or autonomic dysfunction is one of the earliest prodromal symptoms of Parkinson\u2019s disease (PD). It has not been investigated whether PD patients have different phenotypes depending on the presence of these prodromal symptoms. Objective: To investigate whether hyposmia-dominant and dysautonomia-dominant patients with early PD have different clinical manifestations and nigrostriatal degeneration. Methods: This cross-sectional study recruited 168 drug-naive PD patients and 34 control subjects. PD patients were classified as patients without hyposmia and dysautonomia (PD\u2013H\u2013D\u2013, n\u200a=\u200a51), hyposmia-dominant patients (PD\u2013H+D\u2013, n\u200a=\u200a36), dysautonomia-dominant patients (PD\u2013H\u2013D+, n\u200a=\u200a33), and patients with hyposmia and dysautonomia (PD\u2013H+D+, n\u200a=\u200a48). We then compared the baseline clinical characteristics, striatal specific to non-specific binding ratio (SNBR), neuropsychological performance, and neuropsychiatric symptoms among the groups. Results: The PD\u2013H+D\u2013group had a lower SNBR in the ventral striatum (p\u200a=\u200a0.013), a greater asymmetric index of striatal SNBRs, and higher prevalence of apathy (p\u200a=\u200a0.021) than the PD\u2013H\u2013D+ group. The PD\u2013H\u2013D+ group had older age at onset (p\u200a=\u200a0.043) and a higher prevalence of REM sleep behavior disorder (p\u200a=\u200a0.041) than the PD\u2013H+D\u2013group. The PD\u2013H+D+ group had higher motor deficits, lower cognitive function, and lower SNBRs in all striatal subregions than the PD\u2013H\u2013D\u2013group. Decreased SNBRs in the anterior caudate, posterior caudate, and ventral striatum were associated with the presence of apathy. Conclusion: The present study suggests that hyposmia-dominant and dysautonomia-dominant PD have different clinical characteristics and patterns of striatal dopamine depletion.<\/jats:p>","DOI":"10.3233\/jpd-212747","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T14:32:38Z","timestamp":1626186758000},"page":"1703-1713","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and Dopamine Depletion Patterns in Hyposmia- and Dysautonomia-Dominant Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"11","author":[{"given":"Han Soo","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Seok","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young H.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijin","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil Hyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"},{"name":"Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"Pt 5","key":"10.3233\/JPD-212747_ref1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson\u2019s disease: Substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.3233\/JPD-212747_ref2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease","volume":"16","author":"Peng","year":"2020","journal-title":"Nat Rev 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