{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:24:45Z","timestamp":1788481485477,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2022,1,21]]},"abstract":"<jats:p>Background: MRI-guided focused ultrasound (FUS) has established short-term efficacy in tremor relief. Objective: We report our long-term experience of treating tremor with unilateral FUS unilateral VIM-thalamotomy in tremor dominant Parkinson\u2019s disease (TDPD) patients. Methods: We report outcome of FUS thalamotomy in TDPD patients with 1\u20135 years of follow-up. Outcomes: tremor reduction assessed with Clinical Rating Scale for Tremor (CRST) and Unified Parkinson\u2019s Disease Rating Scale (UPDRS part III) overall and in the treated hemibody and safety. Results: Twenty-six TDPD patients completed 1\u20135 years of follow-up (median follow-up 36 months, range 12\u201360 months). Median age was 60 years (range 46\u201379), with median disease duration of 6 years (range 2\u201316). Immediately, treatment resulted in 100%improvement in tremor in the treated arm in 23 patients and 90%improvement in 3 patients. In 15 patients with leg tremor, 2 patients with chin tremor and 1 patient with head tremor, tremor was significantly improved. Up to 5 years, median CRST score, median UPDRS score, overall and in treated hemibody, decreased significantly as compared with baseline (p\u200a&lt;\u200a0.0001). In 2 patients tremor returned completely and in 8 patients there was partial return of tremor. Adverse events were mild and resolved within 3 months. At baseline 4 patients were not receiving any medication vs. 3 at last follow-up and 15 were not taking levodopa vs.9 at last follow-up. Conclusion: Unilateral FUS VIM-thalamotomy in TDPD patients was effective and safe and provided long-term tremor relief in most patients. FUS thalamotomy for tremor may delay initiation of levodopa treatment.<\/jats:p>","DOI":"10.3233\/jpd-212810","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T17:49:11Z","timestamp":1632851351000},"page":"199-206","source":"Crossref","is-referenced-by-count":59,"title":["Focused Ultrasound Thalamotomy in Tremor Dominant Parkinson\u2019s Disease: Long-Term Results"],"prefix":"10.1177","volume":"12","author":[{"given":"Alon","family":"Sinai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nassar","sequence":"additional","affiliation":[{"name":"Movement Disorders Institute, Department of Neurology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Movement Disorders Institute, Department of Neurology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menashe","family":"Zaaroor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Movement Disorders Institute, Department of Neurology, Rambam Health Care Campus, Haifa, Israel"},{"name":"Technion Faculty of Medicine, Haifa, 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