{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:58:38Z","timestamp":1792292318817,"version":"4.4.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2022,5,24]]},"abstract":"<jats:p>Background: The association between restless legs syndrome (RLS) and Parkinson\u2019s disease (PD) remains controversial, with epidemiologic and descriptive evidence suggesting some potential overlap while mechanistic\/genetic studies suggesting relative independence of the conditions. Objective: To examine a known, objectively measured endophenotype for RLS, periodic leg movements (PLMS) in sleep, in patients with PD and relate that objective finding to restless legs symptoms. Methods: We performed polysomnography for one (n\u200a=\u200a8) or two (n\u200a=\u200a67) consecutive nights in 75 PD patients and examined the association of PLMS with restless legs symptoms. Results: We found no association between restless legs symptoms and PLMS in PD. Prevalence of both was similar to data reported previously in other PD samples. Conclusion: We interpret these results as suggesting that restless legs symptoms in PD patients may represent a different phenomenon and pathophysiology than RLS in the non-PD population.<\/jats:p>","DOI":"10.3233\/jpd-213100","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T12:16:49Z","timestamp":1647346609000},"page":"1339-1344","source":"Crossref","is-referenced-by-count":14,"title":["Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Donald L.","family":"Bliwise","sequence":"first","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias G.","family":"Karroum","sequence":"additional","affiliation":[{"name":"Department of Neurology, George Washington University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia A.","family":"Greer","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart A.","family":"Factor","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn Marie","family":"Trotti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JPD-213100_ref1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.5665\/sleep.3416","article-title":"Restless legs syndrome: An early clinical feature of Parkinson\u2019s disease in 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