{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:14:48Z","timestamp":1790630088022,"version":"4.1.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:p>Background: Parkinson\u2019s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia.<\/jats:p>","DOI":"10.3233\/jpd-223232","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T11:57:09Z","timestamp":1653047829000},"page":"1507-1526","source":"Crossref","is-referenced-by-count":2,"title":["Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications"],"prefix":"10.1177","volume":"12","author":[{"given":"Quentin","family":"Devignes","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, Lille Neurosciences and Cognition, CHU-Lille, Neurology and Movement Disorders department, NS-Park\/F-CRIN, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PREDISTIM working group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Daoudi","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, Lille Neurosciences and Cognition, CHU-Lille, Neurology and Movement Disorders department, NS-Park\/F-CRIN, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Viard","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, US 41 \u2013 UMS 2014 \u2013 PLBS, CHU Lille, Lille Pasteur Institute, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Lopes","sequence":"additional","affiliation":[{"name":"Univ. 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