{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:47Z","timestamp":1791908327480,"version":"4.3.4"},"reference-count":79,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:p>Background: Previous reviews indicated positive effects of resistance training (RT) on motor outcomes in Parkinson\u2019s disease (PD). However, inconsistencies between the included studies exist, and non-motor outcomes have only scarcely been considered in a review on RT in PD. Objective: To analyze the RT effects on motor- and non-motor outcomes in PD patients compared to passive and physically active control groups (i.e., other structured physical interventions). Methods: We searched CENTRAL, MEDLINE, EMBASE, and CINAHL for randomized controlled trials of RT in PD. After identifying 18 studies, a meta-analysis was conducted for the outcomes muscle strength, motor impairment, freezing of gait (FoG), mobility and balance, quality of life (QoL), depression, cognition, and adverse events. Meta-analyses with random models were calculated using mean differences (MD) or standardized mean differences (SMD) with 95% confidence intervals (CI). Results: When comparing RT with passive control groups, the meta-analyses showed significant large effects on muscle strength (SMD\u200a=\u200a\u20130.84, 95% CI \u20131.29\u2013\u20130.39, p\u200a=\u200a0.0003), motor impairment (SMD\u200a=\u200a\u20130.81, 95% CI \u20131.34\u2013\u20130.27, p\u200a=\u200a0.003), mobility and balance (MD\u200a=\u200a\u20131.81, 95% CI \u20133.13\u2013\u20130.49, p\u200a=\u200a0.007), and small significant effects on QoL (SMD\u200a=\u200a\u20130.48, 95% CI \u20130.86\u2013\u20130.10, p\u200a=\u200a0.01). RT compared with physically active control groups reached no significant results for any outcome. Conclusions: RT improves muscle strength, motor impairment, mobility and balance, QoL, and depression in PD patients. However, it is not superior to other physically active interventions. Therefore, exercise is important for PD patients but according to this analysis, its type is of secondary interest.<\/jats:p>","DOI":"10.3233\/jpd-223252","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T11:44:15Z","timestamp":1656071055000},"page":"1783-1806","source":"Crossref","is-referenced-by-count":31,"title":["Effects of Resistance Training on Motor- and Non-Motor Symptoms in Patients with Parkinson\u2019s Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"12","author":[{"given":"Romina","family":"Gollan","sequence":"first","affiliation":[{"name":"Medical Psychology, Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Ernst","sequence":"additional","affiliation":[{"name":"Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Lieker","sequence":"additional","affiliation":[{"name":"Medical Psychology, Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Caro-Valenzuela","sequence":"additional","affiliation":[{"name":"Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Monsef","sequence":"additional","affiliation":[{"name":"Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Dresen","sequence":"additional","affiliation":[{"name":"Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR), Faculty of Human Sciences and Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Roheger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universitymedicine Greifswald, Greifswald, 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Physiol"},{"key":"10.3233\/JPD-223252_ref4","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/mds.22609","article-title":"Bradykinesia, muscle weakness and reduced muscle power in Parkinson\u2019s disease","volume":"24","author":"Allen","year":"2009","journal-title":"Mov Disord"},{"key":"10.3233\/JPD-223252_ref5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/NPT.0000000000000244","article-title":"Lower extremity muscle strength and force variability in persons with Parkinson disease","volume":"43","author":"Skinner","year":"2019","journal-title":"J Neurol Phys Ther"},{"key":"10.3233\/JPD-223252_ref6","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/mds.25380","article-title":"A two-year randomized controlled trial of progressive resistance exercise for Parkinson\u2019s disease","volume":"28","author":"Corcos","year":"2013","journal-title":"Mov Disord"},{"key":"10.3233\/JPD-223252_ref7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/rnj.0000000000000179","article-title":"Examining factors related to health-related quality of life in people with Parkinson\u2019s disease","volume":"45","author":"Kwok","year":"2020","journal-title":"Rehabil Nurs"},{"key":"10.3233\/JPD-223252_ref8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/CIA.S231359","article-title":"Progressive resistance training improves bradykinesia, motor symptoms and functional performance in patients with Parkinson\u2019s disease","volume":"15","author":"Vieira de Moraes Filho","year":"2020","journal-title":"Clin Interv Aging"},{"key":"10.3233\/JPD-223252_ref9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0269215513507462","article-title":"Leg muscle power is enhanced by training in people with Parkinson\u2019s disease: A randomized controlled trial","volume":"28","author":"Paul","year":"2014","journal-title":"Clin 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In Recent Development in Parkinson\u2019s Disease,Vol. 2, Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Macmillan Health Care Information, Florham Park, NJ, pp. 153\u2013163, 293\u2013304."},{"key":"10.3233\/JPD-223252_ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1353-8020(99)00062-0","article-title":"Construction of freezing of gait questionnaire for patients with Parkinsonism","volume":"6","author":"Giladi","year":"2000","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JPD-223252_ref26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cUp & Go\u201d: A test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JPD-223252_ref27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ageing\/26.5.353","article-title":"The Parkinson\u2019s Disease Questionnaire (PDQ-39): Development and validation of a Parkinson\u2019s disease summary index score","volume":"26","author":"Jenkinson","year":"1997","journal-title":"Age Ageing"},{"key":"10.3233\/JPD-223252_ref28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"Beck depression inventory (BDI)","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JPD-223252_ref29","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JPD-223252_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184.ch8"},{"key":"10.3233\/JPD-223252_ref31","first-page":"651","article-title":"Effects of progressive resistance exercise in akinetic-rigid Parkinson\u2019s disease patients: A randomized controlled trial","volume":"53","author":"Santos","year":"2017","journal-title":"Eur J Phys Rehabil Med"},{"key":"10.3233\/JPD-223252_ref32","first-page":"173","article-title":"Balance versus resistance training on postural control in patients with Parkinson\u2019s disease: A randomized controlled trial","volume":"53","author":"Santos","year":"2016","journal-title":"Eur J Phys Rehabil Med"},{"key":"10.3233\/JPD-223252_ref33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.gaitpost.2017.12.027","article-title":"Balance and fear of falling in subjects with Parkinson\u2019s disease is improved after exercises with motor complexity","volume":"61","author":"Silva-Batista","year":"2018","journal-title":"Gait Posture"},{"key":"10.3233\/JPD-223252_ref34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/1467-8721.ep10768783","article-title":"Statistical power analysis","volume":"1","author":"Cohen","year":"1992","journal-title":"Curr Dir Psychol Sci"},{"key":"10.3233\/JPD-223252_ref35","doi-asserted-by":"crossref","unstructured":"Higgins JPT , Li T , Deeks JJ (2019) Chapter 6: Choosing effect measures and computing estimates of effect. 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