{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:29:05Z","timestamp":1783607345784,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2022,7,12]]},"abstract":"<jats:p>Multiple system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder of the adulthood, characterized by autonomic failure, parkinsonian and cerebellar features in various combinations. Distinguishing MSA from common clinical look-alikes such as Parkinson's disease, other atypical parkinsonian disorders or alternative causes of sporadic adult-onset cerebellar ataxia may be difficult, especially at early disease stages. Nonetheless, some simple and cost-effective screening tools help detecting important red flags guiding towards a MSA diagnosis. Here we outline which clinical pearls and bedside tests may disclose autonomic dysfunction in multiple domains, enabling an early MSA diagnosis and, even more importantly, personalized treatment.<\/jats:p>","DOI":"10.3233\/jpd-223357","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T11:59:54Z","timestamp":1657627194000},"page":"2277-2281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Bedside Assessment of Autonomic Dysfunction in Multiple System Atrophy"],"prefix":"10.1177","volume":"12","author":[{"given":"Nicole","family":"Campese","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Leys","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor K.","family":"Wenning","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fanciulli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1311488"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05746-6"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29005"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008208"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120407"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00036"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-020-00679-0"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25834"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25170"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27635"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-223357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-223357","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-223357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:52:04Z","timestamp":1777611124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-223357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,12]]}},"alternative-id":["10.3233\/JPD-223357"],"URL":"https:\/\/doi.org\/10.3233\/jpd-223357","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]}}}