{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:07Z","timestamp":1792260427051,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patient perspectives on meaningful symptoms and impacts in early Parkinson\u2019s disease (PD) are lacking and are urgently needed to clarify priority areas for monitoring, management, and new therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine experiences of people with early-stage PD, systematically describe meaningful symptoms and impacts, and determine which are most bothersome or important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty adults with early PD who participated in a study evaluating smartwatch and smartphone digital measures (WATCH-PD study) completed online interviews with symptom mapping to hierarchically delineate symptoms and impacts of disease from \u201cMost bothersome\u201d to \u201cNot present,\u201d and to identify which of these were viewed as most important and why. Individual symptom maps were coded for types, frequencies, and bothersomeness of symptoms and their impacts, with thematic analysis of narratives to explore perceptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The three most bothersome and important symptoms were tremor, fine motor difficulties, and slow movements. Symptoms had the greatest impact on sleep, job functioning, exercise, communication, relationships, and self-concept\u2014 commonly expressed as a sense of being limited by PD. Thematically, most bothersome symptoms were those that were personally limiting with broadest negative impact on well-being and activities. However, symptoms could be important to patients even when not present or limiting (e.g., speech, cognition).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Meaningful symptoms of early PD can include symptoms that are present or anticipated future symptoms that are important to the individual. Systematic assessment of meaningful symptoms should aim to assess the extent to which symptoms are personally important, present, bothersome, and limiting<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-225068","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:25:47Z","timestamp":1684236347000},"page":"619-632","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Relative Meaningfulness and Impacts of Symptoms in People with Early-Stage Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Jennifer R.","family":"Mammen","sequence":"first","affiliation":[{"name":"University of Rhode Island, College of Nursing, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Speck","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn L.T.M.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip T.","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Campbell","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Cosman","sequence":"additional","affiliation":[{"name":"Abbvie Inc., North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien","family":"Dam","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hellsten","sequence":"additional","affiliation":[{"name":"H. Lundbeck A\/S, Valby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Jensen-Roberts","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kostrzebski","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly Ward","family":"Barowicz","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse M.","family":"Cedarbaum","sequence":"additional","affiliation":[{"name":"Coeruleus Clinical Sciences LLC, Woodbridge, CT, USA"},{"name":"Yale Medical School, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ray","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Critical Path Institute, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Adams","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester, Rochester, NY, 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SpeckR, StebbinsG, M\u00fcllerM, YangP, CampbellM, CosmanJ, CrawfordJ, DamT, HellstenJ, Jensen-RobertsS, KostrzebskiM, SimuniT, Ward BarowiczK, CedarbaumJ, DorseyE, StephensonD, AdamsJ (2022) Mapping meaningful symptoms and impacts of disease to digital outcome measures, https:\/\/digitalcommons.uri.edu\/nursing_facpubs\/343\/."},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2015.12.011"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1177\/1049732305276687"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-5251-4_103"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1177\/1049732303013006008"},{"key":"ref025","unstructured":"Salda\u00f1aJ (2013) The Coding Manual for Qualitative Researchers, Sage, Washington, DC."},{"key":"ref026","unstructured":"MaxwellJA (2012) Qualitative Research Design: An Interactive Approach, Sage, Thousand Oaks, 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