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Patients in this advanced PD stage may benefit from alternative therapy, such as continuous intrajejunal delivery of levodopa-carbidopa intestinal gel (LCIG; or carbidopa-levodopa enteral suspension), continuous intrajejunal delivery of levodopa-carbidopa-entacapone intestinal gel, or continuous subcutaneous apomorphine infusion. Consideration and initiation of infusion therapies in advanced PD are suggested before the onset of major disability. The present review summarizes clinical evidence for infusion therapy in advanced PD management, discusses available screening tools for advanced PD, and provides considerations around optimal use of infusion therapy.<\/jats:p>","DOI":"10.3233\/jpd-225112","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T10:31:03Z","timestamp":1686652263000},"page":"641-657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Infusion Therapies in the Treatment of Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Teus","family":"van Laar","sequence":"first","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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