{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:01:04Z","timestamp":1790650864699,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPD"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:p>\u00a0Converging lines of evidence suggest that aerobic exercise impacts Parkinson\u2019s disease (PD) motor symptoms and might slow it\u2019s progression. We provide an overview of the ongoing randomized clinical trials (RCTs) on aerobic exercise in PD. We found six RCTs with sample sizes between 28 and 370 and a follow-up between 8 weeks and 18 months. PD motor symptoms is mostly used as primary outcome while various secondary outcomes are reported. We need more trials that use both clinical endpoints and markers of neuroplasticity, and provide insight into the optimal exercise mode, duration and intensity.<\/jats:p>","DOI":"10.3233\/jpd-229006","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:36:07Z","timestamp":1667306167000},"page":"2297-2306","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Trial Highlights \u2013 Aerobic Exercise for Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Sabine","family":"Schootemeijer","sequence":"first","affiliation":[{"name":"Department of Neurology, Center of Expertise for Parkinson & Movement Disorders, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirwan K.L.","family":"Darweesh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center of Expertise for Parkinson & Movement Disorders, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke M.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center of Expertise for Parkinson & Movement Disorders, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JPD-229006_ref1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1007\/s13311-020-00904-8","article-title":"Current Perspectives on Aerobic Exercise in People with Parkinson\u2019sDisease","volume":"17","author":"Schootemeijer","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JPD-229006_ref2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1177\/1545968320952799","article-title":"Physiotherapy inParkinson\u2019s Disease: A Meta-Analysis of Present TreatmentModalities","volume":"34","author":"Radder","year":"2020","journal-title":"Neurorehabil Neural Repair"},{"key":"10.3233\/JPD-229006_ref3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/mds.26363","article-title":"Nonpharmacological treatments for patients with Parkinson\u2019s disease","volume":"30","author":"Bloem","year":"2015","journal-title":"Mov Disord"},{"key":"10.3233\/JPD-229006_ref4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/ane.13579","article-title":"Parkinson\u2019s disease and intensive exercise therapy \u2013An updated systematic review and meta-analysis","volume":"145","author":"Gamborg","year":"2022","journal-title":"Acta Neurol Scand"},{"key":"10.3233\/JPD-229006_ref5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrneurol.2017.128","article-title":"Long-term effects of exercise and physical therapy in people with Parkinson disease","volume":"13","author":"Mak","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JPD-229006_ref6","doi-asserted-by":"crossref","unstructured":"Feller D , Fox I , Gozzer P , Trentin F , Papola D (2022) Exercise for depressive symptoms in Parkinson\u2019s disease: A systematic review and meta \u2013 analysis of randomized controlled trials. 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