{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:28:07Z","timestamp":1791908887978,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The role of blood uric acid as a biomarker in symptomatic motor PD has been increasingly established in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our present study assessed the role of serum uric acid as a putative biomarker in a prodromal PD cohort [REM Sleep Behavior disorder (RBD) and Hyposmia] followed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Longitudinal 5-year serum uric acid measurement data of 39 RBD patients and 26 Hyposmia patients with an abnormal DATSCAN imaging were downloaded from the Parkinson\u2019s Progression Markers Initiative database. These cohorts were compared with 423 de novo PD patients and 196 healthy controls enrolled in the same study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After adjusting for age, sex, body mass index, and concomitant disorders (hypertension\/gout), baseline and longitudinal serum uric acid levels were higher in the RBD subgroup as compared to the established PD cohort ( p\u200a=\u200a0.004 and p\u200a=\u200a0.001). (Baseline RBD 6.07\u00b11.6 vs. Baseline PD 5.35\u00b11.3\u200amg\/dL and Year-5 RBD 5.7\u00b11.3 vs. Year-5 PD 5.26\u00b11.33). This was also true for longitudinal measurements in the Hyposmic subgroup ( p\u200a=\u200a0.008) (Baseline Hyposmic 5.7\u00b11.6 vs. PD 5.35\u00b11.3\u200amg\/dL and Year-5 Hyposmic 5.58\u00b11.6 vs. PD 5.26\u00b11.33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results indicate that serum uric acid levels are higher in prodromal PD subjects with ongoing dopaminergic degeneration compared to those with manifest PD. These data indicate that the well-established decrease in the levels of serum uric acid occurs with the transition from prodromal to clinical PD. Whether the higher levels of serum uric acid observed in prodromal PD may provide protection against conversion to full-blown clinical PD will require further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230007","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T12:12:22Z","timestamp":1688472742000},"page":"811-818","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson\u2019s Disease: Longitudinal Data from the PPMI Study"],"prefix":"10.1177","volume":"13","author":[{"given":"Christos","family":"Koros","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina-Maria","family":"Simitsi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Papagiannakis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Bougea","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Prentakis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Nuclear Medicine Unit, Attikon Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Henry Dunan Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Pachi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Beratis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Stanitsa","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthalia","family":"Angelopoulou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roubina","family":"Antonelou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Bregianni","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Lourentzos","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokratis G.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Bonakis","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia Geronicola","family":"Trapali","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Attikon Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stamelou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Neurology Clinic, Philipps University, Marburg, Germany"},{"name":"Parkinsons disease and Movement Disorders Dept., HYGEIA Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, 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