{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:50:32Z","timestamp":1791402632778,"version":"4.3.3"},"reference-count":54,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2023,10,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Some reports suggest that psychotic features may occur in the early stages of Parkinson\u2019s disease (PD), but sensitive tools have not been utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim was to evaluate the presence of psychotic symptoms using detailed scales and to assess the association with clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Healthy controls and patients within three years of PD onset were recruited. Participants were examined for psychotic symptoms using two different instruments: the Comprehensive Assessment of At-Risk Mental States (CAARMS) and a 10 question PD specific psychosis severity scale (10PDQ). In the PD group, medication use, motor and non-motor symptoms were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Based on CAARMS and 10PDQ scales, psychotic features were present in 39% (27\/70) of patients and 4% (3\/74) of controls. The prevalence of passage hallucinations and illusions was significantly higher in PD compared to the control group. The presence of PD-associated psychotic features was not significantly affected by medication, motor severity or global cognitive status. Higher prevalence of overall non-motor manifestations, REM sleep behavior disorder (RBD) and depressive symptoms was significantly associated with the manifestation of psychotic features in PD [(adjusted OR:1.3; 95% CI:1.1-1.6; p\u200a=\u200a0.003), (adjusted OR:1.3; 95% CI:1.0-1.6; p\u200a=\u200a0.023), and (adjusted OR:1.2; 95% CI:1.0-1.4; p\u200a=\u200a0.026)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Psychotic phenomena mainly of minor nature are highly common in early PD. Cumulative non-motor symptoms, RBD and depressive features are associated with the presence of psychotic symptoms in this non-demented, early-stage PD population. More studies are needed to clarify the mechanisms that contribute to the onset of psychotic features in early PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230056","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:16:27Z","timestamp":1696940187000},"page":"1185-1197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive Evaluation of Psychotic Features and Their Clinical Correlates in Early Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Ioanna","family":"Pachi","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Koros","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina Maria","family":"Simitsi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Bougea","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bozi","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Papagiannakis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigas Filippos","family":"Soldatos","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Kolovou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Pantes","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Taub Institute for Research in Alzheimer\u2019s Disease and the Aging Brain, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Paraskevas","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Voumvourakis","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokratis G.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kollias","sequence":"additional","affiliation":[{"name":"1st Department of Psychiatry, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Stefanis","sequence":"additional","affiliation":[{"name":"1st Department of Psychiatry, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21382"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0600-5"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26432"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191325.31068.c4"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21875"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10186"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"ref010","unstructured":"SchwabRS, EnglandAC (1969) Projection technique for evaluating surgery in Parkinson\u2019s disease. In Third Symposium on Parkinson\u2019s Disease, Billingham FH, Donaldson MC, eds. Churchill Livingstone, Edinburgh, pp. 152-157."},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25037"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24023"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1186\/s40734-015-0024-5"},{"key":"ref018","first-page":"217","volume":"26","author":"Kollias C","year":"2015","journal-title":"Psychiatriki"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029868"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21091"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10217"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20474"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212930"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.166959"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300043"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000801"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13106"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3469706"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181338"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000265593.34438.00"},{"key":"ref031","first-page":"755","volume":"25","author":"F\u00e9nelon G","year":"2010","journal-title":"MovDisord"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51102"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140523"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.200"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.06.010"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S130997"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005421"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20582"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.11.018"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147477"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27557"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2021.507"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00933.x"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.12.025"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000141853.27081.BD"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.09.015"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.10.013"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14576"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.01.004"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.11.001"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26170"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13376"},{"key":"ref053","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.35"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000602"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-230056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-230056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-230056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:52:49Z","timestamp":1777611169000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-230056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10,9]]}},"alternative-id":["10.3233\/JPD-230056"],"URL":"https:\/\/doi.org\/10.3233\/jpd-230056","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]}}}