{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:58:23Z","timestamp":1777888703545,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nocturnal symptoms have a significant effect on the quality of life in Parkinson\u2019s disease (PD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter cross-sectional study included 1,500 patients with primary PD from 18 centers in China was carried out between February 2019 and February 2020. Questionnaires including Parkinson\u2019s disease sleep scale 2 (PDSS-2), Parkinson\u2019s disease questionnaire 8 (PDQ-8), Beck depression inventory (BDI), and generalized anxiety disorder scale 7 (GAD-7) were used to assess nocturnal symptoms, quality of life, depression, and anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 1,500 Chinese PD patients, 576 (38.4%) reported nocturnal symptoms. Of them, 59.2% were older than 65 years. The PDQ-8 total score was higher in patients with nocturnal symptoms ( p\u200a&lt;\u200a0.01). Moderate and severe depression was reported more often in patients with nocturnal symptoms ( p\u200a&lt;\u200a0.01), and the occurrence and severity of anxiety were higher as well ( p\u200a&lt;\u200a0.01). Longer disease duration and higher Hoehn-Yahr (HY) stage were independently associated with nocturnal symptoms ( p\u200a&lt;\u200a0.01). Education level, depression, disease course, HY stage, and nocturnal symptoms were related to the quality of life in Chinese PD patients ( p\u200a&lt;\u200a0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study found that 38.4% of Chinese PD patients have nocturnal symptoms, even in early and mid-stage PD. Nocturnal symptoms were associated with worse quality of life and higher incidences of depression and anxiety. Nocturnal symptoms should be included in the assessment and care plan, especially in patients with longer disease courses and higher HY stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230060","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:28:26Z","timestamp":1690547306000},"page":"1061-1071","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Nocturnal Symptoms in Chinese Parkinson\u2019s Disease Patients           Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study"],"prefix":"10.1177","volume":"13","author":[{"given":"Wen","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of\r          Gerontology, Institute of Geriatric Medicine, Chinese Academy\r          of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of\r          Gerontology, Institute of Geriatric Medicine, Chinese Academy\r          of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of\r          Gerontology, Institute of Geriatric Medicine, Chinese Academy\r          of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital of Sichuan University, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing,\r            China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu,\r          China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Jiangsu,\r          China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial People\u2019s Hospital, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baorong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Internal Medicine-Neurology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang,\r            China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan,\r          Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong,\r            China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated hospital of Anhui Medical University, Anhui,\r   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