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In our study, we analyzed cerebrospinal fluid samples from 121 PD patients recruited through population screening methods and taken within a median delay of 38 days from diagnosis and 51 normal controls without neurodegenerative disease. SAA yielded a sensitivity of 82.6% (95% CI, 74.7% \u2013 88.9%) and specificity of 88.2% (95% CI, 76.1% \u2013 95.6%). These results highlight the potential of SAA to support the initial diagnosis of PD in clinical practice and research.<\/jats:p>","DOI":"10.3233\/jpd-230065","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:22:15Z","timestamp":1688124135000},"page":"841-844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Linn","family":"Oftedal","sequence":"first","affiliation":[{"name":"Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Maple-Gr\u00f8dem","sequence":"additional","affiliation":[{"name":"Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway"},{"name":"Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole-Bj\u00f8rn","family":"Tysnes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Alves","sequence":"additional","affiliation":[{"name":"Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway"},{"name":"Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway"},{"name":"Department of Neurology, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Lange","sequence":"additional","affiliation":[{"name":"Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway"},{"name":"Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111842"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.338"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0508-2"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27646"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02160-8"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29329"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.168211"},{"key":"ref008","first-page":"165","volume":"39","author":"Daniel SE","year":"1993","journal-title":"J Neural Transm Suppl"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000425"},{"key":"ref010","unstructured":"Ltd. 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