{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:31:10Z","timestamp":1793727070137,"version":"4.6.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2023,10,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Little is known about the burden of parkinsonism and Parkinson\u2019s disease (PD) in Latin America. Better understanding of health service use and clinical outcomes in PD is needed to improve its prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the study was to estimate the burden of parkinsonism and PD in six Latin American countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>12,865 participants aged 65 years and older from the 10\/66 population-based cohort study were analysed. Baseline assessments were conducted in 2003\u20132007 and followed-up 4 years later. Parkinsonism and PD were defined using current clinical criteria or self-reported diagnosis. Logistic regression models assessed the association between parkinsonism\/PD with baseline health service use (community-based care or hospitalisation in the last 3 months) and Cox proportional hazards regression models with incident dependency (subjective assessment by interviewer based on informant interview) and mortality. Separate analyses for each country were combined via fixed effect meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At baseline, the prevalence of parkinsonism and PD was 7.9% ( n\u200a=\u200a934) and 2.6% ( n\u200a=\u200a317), respectively. Only parkinsonism was associated with hospital admission at baseline (OR 1.89, 95% CI 1.30\u20132.74). Among 7,296 participants without dependency at baseline, parkinsonism (HR 2.34, 95% CI 1.81\u20133.03) and PD (2.10, 1.37\u20133.24) were associated with incident dependency. Among 10,315 participants with vital status, parkinsonism (1.73, 1.50\u20131.99) and PD (1.38, 1.07\u20131.78) were associated with mortality. The Higgins I\n                      <jats:sup>2<\/jats:sup>\n                      tests showed low to moderate levels of heterogeneity across countries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings show that older people with parkinsonism or PD living in Latin America have higher risks of developing dependency and mortality but may have limited access to health services.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230114","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:42:50Z","timestamp":1695382970000},"page":"1199-1211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Burden of Parkinsonism and Parkinson\u2019s Disease on Health Service Use and Outcomes in Latin America"],"prefix":"10.1177","volume":"13","author":[{"given":"Dani J.","family":"Kim","sequence":"first","affiliation":[{"name":"Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King\u2019s College London, London, UK"},{"name":"Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Rodriguez-Salgado","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute, University of San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Llibre-Rodriguez","sequence":"additional","affiliation":[{"name":"Dementia Research Unit, Medical University of Havana, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Acosta","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico"},{"name":"National Autonomous University of Mexico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luisa","family":"Sosa","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico"},{"name":"National Autonomous University of Mexico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Acosta","sequence":"additional","affiliation":[{"name":"Universidad Nacional Pedro Henriquez Ure\u00f1a (UNPHU), Internal Medicine Department, Geriatric Section, Santo Domingo, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne Z.","family":"Jimenez-Velasquez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Guerra","sequence":"additional","affiliation":[{"name":"Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aquiles","family":"Salas","sequence":"additional","affiliation":[{"name":"Medicine Department, Caracas University Hospital, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jeyachandran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"L\u00f3pez-Contreras","sequence":"additional","affiliation":[{"name":"Memory Clinic, Neurology Service, Salvadoran Social Security Institute, San Salvador, El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Hesse","sequence":"additional","affiliation":[{"name":"Observatorio Covid-19, Universidad Tecnol\u00f3gica Centroamericana, Tegucigalpa, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences, University of California-San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Llibre-Guerra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Prina","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle 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