{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:03:24Z","timestamp":1790996604719,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,2,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-motor symptoms (NMS) reduce quality of life in Parkinson\u2019s disease (PD) patients, who experience three times more NMS than individuals without PD. While there are international and national NMS treatment guidelines, their implication in clinical practice remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the adherence to pharmacological NMS treatment guidelines in patients with mild to moderately severe PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>220 PD patients with \u22651 NMS based on the Non-Motor Symptom Questionnaire and a Hoehn and Yahr stage \u22644 were randomly selected from the Swedish Parkinson registry and screened for inclusion. NMS were evaluated using the International Parkinson and Movement Disorder Society\u2013Non-Motor Rating Scale (MDS-NMS), Parkinson\u2019s Disease Sleep Scale 2, Epworth Sleepiness Scale, and Hospital Anxiety and Depression Scale. Treatment was compared with Swedish national guidelines and international guidelines from the MDS Evidence-Based Medicine Committee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 165 included patients, the median number of NMS was 14, and in median 7 symptoms were estimated to require treatment. The most common NMS requiring treatment were pain (69%) and urinary problems (56%). Treatment of depression and constipation demonstrated the highest adherence to guidelines (79% and 77%), while dysphagia and excessive daytime sleepiness exhibited the lowest adherence (0% and 4%). On average, only 32% of NMS were treated in accordance with guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adherence to pharmacological guidelines for NMS in patients with mild to severe PD was low. This study highlights the need for improved evaluation and treatment of NMS to enhance symptom management and quality of life among PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230263","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:19:54Z","timestamp":1705061994000},"page":"297-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Non-Motor Symptom Management: Insights into Adherence to Treatment Guidelines in Parkinson\u2019s Disease Patients"],"prefix":"10.1177","volume":"14","author":[{"given":"Carin","family":"Janz","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Timpka","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Rosqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rostock, Rostock, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Rostock-Greifswald, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23826"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827deb74"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-021-01337-3"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2017.05.008"},{"key":"ref007","unstructured":"BergquistF, ConstantinescuR, SegrellND, ErikssonL, GunnarssonK, HolmbergB, JohanssonA, LindG, LinderJ, L\u00f6kkJ, MarktorpC, NyholmD, OdinP, VisseGP, PuschmannA, P\u00e5lhagenS, SvenningssonP, WidnerHSwedish Movement Disorder Society (Swemodis). Guidelines for investigation and treatment of Parkinson\u2019s disease (Riktlinjer f\u00f6r utredning och behandling av Parkinsons sjukdom.) Sweden. Swedmodis; Version #9, 2022.https:\/\/www.swemodis.se\/wp-content\/uploads\/2009\/10\/Swemodis-Riktlinjer-for-utredningoch-behandling-av-Parkinsons-sjukdom-version_8_A4.pdf"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-005-0072-6"},{"key":"ref009","unstructured":"The National Board of Health and Welfare (Socialstyrelsen) (2022) National Guidelines \u2013Indicators for Care in Multiple Sclerosis and Parkinson\u2019s Disease (Nationella riktlinjer \u2013Indikationer f\u00f6r v\u00e5rd vid multipel skleros och Parkinsons sjukdom). https:\/\/www.socialstyrelsen.se\/globalassets\/sharepoint-dokument\/artikelkatalog\/nationella-riktlinjer\/2022-11-8215.pdf"},{"key":"ref010","unstructured":"The National Board of Health and Welfare (Socialstyrelsen) (2022) National Guidelines on care for multiple sclerosis and Parkinson\u2019s Disease. Priority support for decision-makers and managers. 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