{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:15:05Z","timestamp":1792732505915,"version":"4.5.0"},"reference-count":69,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is a serious complication following deep brain stimulation (DBS) but only received little attention. Its main risk factors are higher age and preoperative cognitive deficits. These are also main risk factors for long-term cognitive decline after DBS in Parkinson\u2019s disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify risk factors for POD severity after DBS surgery in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      57 patients underwent DBS (21 female; age 60.2\u00b18.2; disease duration 10.5\u00b15.9 years). Preoperatively, general, PD\u2013 and surgery-specific predictors were recorded. Montreal Cognitive Assessment and the neuropsychological test battery CANTAB Connect\n                      <jats:sup>TM<\/jats:sup>\n                      were used to test domain-specific cognition. Volumes of the cholinergic basal forebrain were calculated with voxel-based morphometry. POD severity was recorded with the delirium scales Confusion Assessment Method for Intensive Care Unit (CAM-ICU) and Nursing Delirium Scale (NU-DESC). Spearman correlations were calculated for univariate analysis of predictors and POD severity and linear regression with elastic net regularization and leave-one-out cross-validation was performed to fit a multivariable model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>21 patients (36.8%) showed mainly mild courses of POD following DBS. Correlation between predicted and true POD severity was significant (spearman rho\u200a=\u200a0.365, p\u200a=\u200a0.001). Influential predictors were age ( p\u200a&lt;\u200a0.001), deficits in attention and motor speed ( p\u200a=\u200a0.002), visual learning ( p\u200a=\u200a0.036) as well as working memory ( p\u200a&lt;\u200a0.001), Nucleus basalis of Meynert volumes ( p\u200a=\u200a0.003) and burst suppression ( p\u200a=\u200a0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>General but also PD\u2013 and surgery-specific factors were predictive of POD severity. These findings underline the multifaceted etiology of POD after DBS in PD. Valid predictive models must therefore consider general, PD\u2013 and surgery-specific factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230276","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T12:45:10Z","timestamp":1721738710000},"page":"1175-1192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"14","author":[{"given":"Melanie","family":"Astalosch","sequence":"first","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahta","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Martins","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Helge","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Stuke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Robert Koch-Institute, Berlin, Germany"},{"name":"Centre for Artificial Intelligence in Public Health Research, Germany; Berlin Center for Advanced Neuroimaging (BCAN), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Haufe","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t, Berlin, Germany"},{"name":"Robert Koch-Institute, Berlin, Germany"},{"name":"Physikalisch-Technische Bundesanstalt, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Borchers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"von Hofen-Hohloch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Al-Fatly","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ebersbach","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic, Kliniken Beelitz GmbH, Beelitz-Heilst\u00e4tten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Berlin School of Mind and Brain, Humboldt - Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"K\u00fcbler-Weller","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Movement Disorder and Neuromodulation Unit, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"ref002","first-page":"e9688","volume":"12","author":"Maheshwary A","year":"2020","journal-title":"Cureus"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000594"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0144"},{"key":"ref005","unstructured":"American Psychiatric Association. 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