{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:13Z","timestamp":1792260433562,"version":"4.4.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,4,13]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>REM-sleep behavior disorder (RBD) and other non-motor symptoms such as hyposmia were proposed by the Movement Disorder Society as research criteria for prodromal Parkinson\u2019s disease (P-PD). Global cognitive deficit was later added.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare non-motor symptoms, focusing on cognition, between a P-PD group and a matched control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this cross-sectional, case-control study, in a first set of analyses, we performed extensive cognitive testing on people with ( n\u200a=\u200a76) and a control group without ( n\u200a=\u200a195) probable RBD and hyposmia. Furthermore, we assessed motor and non-motor symptoms related to Parkinson\u2019s Disease (PD). After propensity score matching, we compared 62 P-PD with 62 age- and sex-matched controls. In addition, we performed regression analyses on the total sample ( n\u200a=\u200a271). In a second set of analyses, we used, a.o., the CUPRO to evaluate retrograde procedural memory and visuo-constructive functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>People with P-PD showed significantly poorer performances in global cognition, visuo-constructive and executive functions, mainly in mental flexibility ( p\u200a&lt;\u200a0.001; p\u200a=\u200a0.004; p\u200a=\u200a0.003), despite similar educational levels ( p\u200a=\u200a0.415). We observed significantly more motor and non-motor symptoms ( p\u200a&lt;\u200a0.001; p\u200a=\u200a0.004), higher scores for depression ( p\u200a=\u200a0.004) and apathy ( p\u200a&lt;\u200a0.001) as well as lower quality of life ( p\u200a&lt;\u200a0.001) in P-PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our findings confirm that global cognitive, executive, and visuo-constructive deficits define the P-PD group. In addition, depression, apathy, and lower quality of life were more prevalent in P-PD. If replicated in other samples, executive and visuo-constructive deficits should be considered in non-motor P-PD. Determining specific patterns will support early recognition of PD, secondary prevention of complications and the development of neuroprotective treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230285","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T11:07:30Z","timestamp":1713870450000},"page":"545-556","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Cognition and Other Non-Motor Symptoms in an At-Risk Cohort for Parkinson\u2019s Disease Defined by REM-Sleep Behavior Disorder and Hyposmia"],"prefix":"10.1177","volume":"14","author":[{"given":"Laure","family":"Pauly","sequence":"first","affiliation":[{"name":"Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Strassen, Luxembourg"},{"name":"Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Parkinson Research Clinic, Luxembourg, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Rauschenberger","sequence":"additional","affiliation":[{"name":"Competence Centre for Methodology and Statistics, Luxembourg Institute of Health (LIH), Strassen, Luxembourg"},{"name":"Biomedical Data Science, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Pauly","sequence":"additional","affiliation":[{"name":"Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Strassen, Luxembourg"},{"name":"Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Parkinson Research Clinic, Luxembourg, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie E.","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Parkinson Research Clinic, Luxembourg, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Van Cutsem","sequence":"additional","affiliation":[{"name":"Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Parkinson Research Clinic, Luxembourg, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja K.","family":"Leist","sequence":"additional","affiliation":[{"name":"Department of Social Sciences, Institute for Research on Socio-Economic Inequality, University of Luxembourg, Esch-sur-Alzette, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejko","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Strassen, Luxembourg"},{"name":"Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"},{"name":"Parkinson Research Clinic, Luxembourg, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the NCER-PD 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