{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:41:02Z","timestamp":1791841262923,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,7,23]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gait disturbance is a vital characteristic of motor manifestation in \u03b1\u2013 synucleinopathies, especially Parkinson\u2019s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before phenoconversion; it is yet unclear, if gait analysis may predict phenoconversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate subtle gait alterations and explore whether gait analysis using wearable sensors is associated with phenoconversion of iRBD to \u03b1-synucleinopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-one polysomnography-confirmed iRBD patients and 33 healthy controls (HCs) were enrolled at baseline. All participants walked for a minute while wearing 6 inertial sensors on bilateral wrists, ankles, and the trunk (sternal and lumbar region). Three conditions were tested: (i) normal walking, (ii) fast walking, and (iii) dual-task walking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Decreased arm range of motion and increased gait variation (stride length, stride time and stride velocity) discriminate converters from HCs at baseline. After an average of 5.40 years of follow-up, 10 patients converted to neurodegenerative diseases (converters). Cox regression analysis showed higher value of stride length asymmetry under normal walking condition to be associated with an early conversion of iRBD to \u03b1\u2013 synucleinopathies (adjusted HR 4.468, 95% CI 1.088\u2013 18.349, p\u200a=\u200a0.038).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Stride length asymmetry is associated with progression to \u03b1\u2013 synucleinopathies in patients with iRBD. Gait analysis with wearable sensors may be useful for screening, monitoring, and risk stratification for disease-modifying therapy trials in patients with iRBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230397","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T11:28:09Z","timestamp":1717759689000},"page":"1027-1037","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study"],"prefix":"10.1177","volume":"14","author":[{"given":"Shanshan","family":"Cen","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing Key Laboratory on Parkinson\u2019s Disease, Parkinson\u2019s Disease Center for Beijing Institute on Brain Disorders, Clinical and Research Center for Parkinson\u2019s Disease of Capital Medical University, Beijing, China"},{"name":"Department of Biobank, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadish K.","family":"Chhetri","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing Key Laboratory on Parkinson\u2019s Disease, Parkinson\u2019s Disease Center for Beijing Institute on Brain Disorders, Clinical and Research Center for Parkinson\u2019s Disease of Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000340980.19702.6e"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00176-9"},{"key":"ref003","first-page":"547","author":"MacKinnon CD","year":"2019","journal-title":"Rapid-Eye-Movement Sleep Behavior Disorder"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad186"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30044-4"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25653"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27780"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26665"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191773"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28894"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.06.008"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2004.827933"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2017.1348690"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00034.2015"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26110"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-2-19"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1063\/1.3147408"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2013.02.006"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2022.08.017"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25161"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26720"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.10.180"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2009.10.013"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140447"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22165"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25548"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00215"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa365"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25606"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010610"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx197"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-230397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-230397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-230397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:53:26Z","timestamp":1777611206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-230397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,7,23]]}},"alternative-id":["10.3233\/JPD-230397"],"URL":"https:\/\/doi.org\/10.3233\/jpd-230397","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]}}}