{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:40:55Z","timestamp":1790095255751,"version":"4.0.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,6,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rapid eye movement sleep behavior disorder (RBD) may precede or follow motor symptoms in Parkinson\u2019s disease (PD). While over 70% of idiopathic RBD cases phenoconvert within a decade, a small subset develops PD after a more extended period or remains nonconverted. These heterogeneous manifestations of RBD in PD prompt subtype investigations. Premotor RBD may signify \u201cbody-first\u201d PD with bottom-up, symmetric synucleinopathy propagation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Explore brainstem and nigrostriatal monoaminergic degeneration pattern differences based on premotor RBD presence and duration in de novo PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In a cross-sectional analysis of de novo PD patients ( n\u200a=\u200a150) undergoing FP-CIT PET and RBD Single-Question Screen, the cohort was categorized into groups with and without premotor RBD (PD\n                      <jats:sup>RBD\u00a0+\/\u2013<\/jats:sup>\n                      ), with further classification of PD\n                      <jats:sup>RBD\u00a0+<\/jats:sup>\n                      based on a 10-year duration of premotor RBD. Analysis of FP-CIT binding in the striatum and pons, striatal asymmetry, and striatum-to-pons ratios compared patterns of nigrostriatal and brainstem monoaminergic degeneration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PD\n                      <jats:sup>RBD\u00a0+<\/jats:sup>\n                      exhibited more severe and symmetrical striatal dopaminergic denervation compared to PD\n                      <jats:sup>RBD\u2013<\/jats:sup>\n                      , with the difference in severity accentuated in the least-affected hemisphere. The PD\n                      <jats:sup>RBD\u00a0+&lt;10Y<\/jats:sup>\n                      subgroup displayed the most prominent striatal symmetry, supporting a more homogeneous \u201cbody-first\u201d subtype. Pontine uptakes remained lower in PD\n                      <jats:sup>RBD\u00a0+<\/jats:sup>\n                      even after adjusting for striatal uptake, suggesting early degeneration of pontine monoaminergic nuclei.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Premotor RBD in PD is associated with severe, symmetrical nigrostriatal and brainstem monoaminergic degeneration, especially in cases with PD onset within 10 years of RBD. This supports the concept of a \u201cwidespread, bottom-up\u201d pathophysiological mechanism associated with premotor RBD in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-230459","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:18:51Z","timestamp":1713269931000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Symmetric and Profound Monoaminergic Degeneration in Parkinson\u2019s Disease with Premotor REM Sleep Behavior Disorder"],"prefix":"10.1177","volume":"14","author":[{"given":"Kyung Ah","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomseok","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26298"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26431"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3468"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13168"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13908"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20140228"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp244"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23677"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e560e"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24939"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.22042"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202481"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004121"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.010"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm056"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa293"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25037"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-012-0159-3"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.138636"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22814-8"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cef824"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12386"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa365"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws253"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28682"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa238"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.2.585"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp209"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.290"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab378"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212761"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26347"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0621-0"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.09.004"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv215"}],"container-title":["Journal 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