{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:57:44Z","timestamp":1777888664682,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>DATATOP was a study of early Parkinson\u2019s disease (PD) conducted in the 1980\u200as, before mandatory folic acid fortification in the United States. Our analysis of its baseline serum samples revealed a geometric mean vitamin B12 of 369\u200apg\/mL and homocysteine (tHcy) of 9.5\u03bcmol\/l. We also found that low B12 predicted greater worsening of ambulatory capacity (AC) and elevated tHcy (&gt;15\u03bcmol\/L) predicted greater declines in cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We sought to measure B12 and tHcy in contemporary trial participants with early PD who had not started dopaminergic treatment and to determine whether these analytes were associated with clinical progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We measured B12 and tHcy from baseline and end-of-study blood samples from three recent clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline geometric mean B12 levels for these studies ranged from 484\u2013 618\u200apg\/ml and for tHcy ranged from 7.4\u2013 10\u03bcmol\/L. Use of B12-containing supplements ranged from 41\u2013 61%, and those taking supplements had higher B12 and lower tHcy. Those who began levodopa, but were not taking B12-supplements, had greater end-of-study tHcy. There was no association of baseline tHcy\u200a&gt;\u200a15\u03bcmol\/L with annualized change in Montreal Cognitive Assessment and no association of baseline B12 tertiles with change in AC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In these longitudinal trials, B12 levels were higher than for DATATOP, due in large part to increased B12-supplement intake, while tHcy levels were similar. Initiation of levodopa was associated with increases of tHcy in those not taking a B12-containing supplement. These smaller studies did not replicate prior findings of low B12 and elevated tHcy with features of progression, possibly due to higher baseline B12.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-240035","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:43:43Z","timestamp":1725363823000},"page":"1243-1255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials"],"prefix":"10.1177","volume":"14","author":[{"given":"Chadwick W.","family":"Christine","sequence":"first","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Auinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Health and Technology, University of Rochester, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A.R.","family":"Forti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyvin","family":"Tat","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshi","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and Statistics, Harvard University, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, 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