{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:33:07Z","timestamp":1784075587672,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:p>Our language affects patients\u2019 perceptions of therapies. In Parkinson\u2019s disease, emergent response fluctuations and dyskinesias typically trigger conversations around commencing an \u201c Advanced Therapy\u201d which carries notions of Advanced Disease. The patient, resolute in their commitment to fighting the disease, is misled. Chasing reassurance that their disease has not yet progressed considerably; they may therefore resist a potentially life-changing therapy. Instead, we should offer a \u201c Smart Therapy\u201d. This term more accurately and positively describes therapies on offer that stabilize response fluctuations and improve quality of life, without a focus on the negative connotations of progression to more advanced disease.<\/jats:p>","DOI":"10.3233\/jpd-240193","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T10:45:53Z","timestamp":1725965153000},"page":"1527-1530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Winding Back the Clock on Advanced Therapies: It\u2019s Time to Get Smart"],"prefix":"10.1177","volume":"14","author":[{"given":"Matthew J.","family":"Georgiades","sequence":"first","affiliation":[{"name":"Parkinson\u2019s Disease Research Clinic, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton A.","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alrijne Hospital, Leiderdorp, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain and Cognition, Department of Neurology, Center of Expertise for Parkinson & Movement Disorders, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease Research Clinic, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196902132800701"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322338"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.06.025"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.06.001"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15386"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28599"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00896"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202104"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-018-0067-z"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809983"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201448"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02668-9"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13648"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27860"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-225112"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29415"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207858"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-240193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-240193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-240193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:53:54Z","timestamp":1777611234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-240193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10,15]]}},"alternative-id":["10.3233\/JPD-240193"],"URL":"https:\/\/doi.org\/10.3233\/jpd-240193","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}