{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:44:12Z","timestamp":1778557452599,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>\n                    \u00a0In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal\/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.\n                  <\/jats:p>","DOI":"10.3233\/jpd-240210","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:53:53Z","timestamp":1720781633000},"page":"1271-1276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions"],"prefix":"10.1177","volume":"14","author":[{"given":"Hendrik","family":"Theis","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"},{"name":"Department of Neurology, University Hospital of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Gottingen, Germany"},{"name":"Institute for Neuroscience and Medicine (INM-2), Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Cologne, Cologne, Germany"},{"name":"Institute for Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Neumaier","sequence":"additional","affiliation":[{"name":"Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Cologne, Germany"},{"name":"Institute of Neuroscience & Medicine (INM-5), Nuclear Chemistry, Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard N.","family":"Bischof","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"},{"name":"Institute for Neuroscience and Medicine (INM-2), Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"van Eimeren","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"},{"name":"Department of Neurology, University Hospital of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02479-4"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04788-w"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00483"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2526"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.339"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05964-w"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27666"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-018-9384-y"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"}],"container-title":["Journal of 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