{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:17:39Z","timestamp":1792113459030,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Enhancing the interactions between study participants, clinicians, and investigators is imperative for advancing Parkinson\u2019s disease (PD) research. The Canadian Open Parkinson Network (C-OPN) stands as a nationwide endeavor, connecting the PD community with ten accredited universities and movement disorders research centers spanning, at the time of this analysis, British Columbia, Alberta, Ontario, and Quebec.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our aim is to showcase C-OPN as a paradigm for bolstering national collaboration to accelerate PD research and to provide an initial overview of already collected data sets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The C-OPN database comprises de-identified data concerning demographics, symptoms and signs, treatment approaches, and standardized assessments. Additionally, it collects venous blood-derived biomaterials, such as for analyses of DNA, peripheral blood mononuclear cells (PBMC), and serum. Accessible to researchers, C-OPN resources are available through web-based data management systems for multi-center studies, including REDCap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>As of November 2023, the C-OPN had enrolled 1,505 PD participants. The male-to-female ratio was 1.77:1, with 83% ( n\u200a=\u200a1098) residing in urban areas and 82% ( n\u200a=\u200a1084) having pursued post-secondary education. The average age at diagnosis was 60.2\u00b110.3 years. Herein, our analysis of the C-OPN PD cohort encompasses environmental factors, motor and non-motor symptoms, disease management, and regional differences among provinces. As of April 2024, 32 research projects have utilized C-OPN resources.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>C-OPN represents a national platform promoting multidisciplinary and multisite research that focuses on PD to promote innovation, exploration of care models, and collaboration among Canadian scientists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-240213","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T10:35:51Z","timestamp":1726828551000},"page":"1481-1494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Advancing Parkinson\u2019s Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort"],"prefix":"10.1177","volume":"14","author":[{"given":"Marisa","family":"Cressatti","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada"},{"name":"Department of Medicine, School of Medicine, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel D.","family":"Pinilla-Monsalve","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut universitaire de g\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Blais","sequence":"additional","affiliation":[{"name":"Axe Neurosciences du Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine P.","family":"Normandeau","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde","family":"Degroot","sequence":"additional","affiliation":[{"name":"McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kathol","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bogard","sequence":"additional","affiliation":[{"name":"McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bendas","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut universitaire de g\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada"},{"name":"Parkinson and Movement Disorders Program and the Complex Neurologic Symptoms Clinic, Kaye Edmonton Clinic, University of Alberta, Edmonton, AB, Canada"},{"name":"Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"Axe Neurosciences du Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Faculty of Medicine, Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Gan-Or","sequence":"additional","affiliation":[{"name":"McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Division of Neurology and Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine V.","family":"Kalia","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"},{"name":"Morton and Gloria Shulman Movement Disorder Unit and the E. J. Safra Parkinson Disease Program, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny A.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute, University of Western Ontario, London, ON, Canada"},{"name":"Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"McKeown","sequence":"additional","affiliation":[{"name":"Pacific Parkinson\u2019s Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis M.","family":"Miyasaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada"},{"name":"Parkinson and Movement Disorders Program and the Complex Neurologic Symptoms Clinic, Kaye Edmonton Clinic, University of Alberta, Edmonton, AB, Canada"},{"name":"Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Schlossmacher","sequence":"additional","affiliation":[{"name":"Division of Neurology and Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Jon","family":"Stoessl","sequence":"additional","affiliation":[{"name":"Pacific Parkinson\u2019s Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorder Unit and the E. J. Safra Parkinson Disease Program, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Brain, Imaging and Behaviour \u2013 Systems Neuroscience, Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, CAMH, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Fon","sequence":"additional","affiliation":[{"name":"McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oury","family":"Monchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada"},{"name":"Centre de Recherche de l\u2019Institut universitaire de g\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada"},{"name":"D\u00e9partement de radiologie, radio-oncologie et m\u00e9decine nucl\u00e9aire, Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181374"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30295-3"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx118"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007856"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000384"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa238"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191775"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v45i10a01"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"ref012","first-page":"e12144","volume":"13","author":"Katz MJ","year":"2021","journal-title":"Alzheimers Dement"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23429"},{"key":"ref014","first-page":"1738","volume":"73","author":"Hoops S","year":"2009","journal-title":"J Neurol"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.995438"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.08.018"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.415"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2019.27"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.09.005"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.04.012"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23934"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00326"},{"key":"ref023","first-page":"e698","volume":"99","author":"Grover S","year":"2022","journal-title":"J Neurol"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn031"},{"key":"ref025","first-page":"168","volume":"87","author":"Mollenhauer B","year":"2016","journal-title":"J Neurol"},{"key":"ref026","first-page":"406","volume":"83","author":"Adler CH","year":"2014","journal-title":"J Neurol"},{"key":"ref027","unstructured":"KhanM. 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