{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T19:00:46Z","timestamp":1780686046918,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Richard & Shauna Elias Charitable Fund"},{"name":"Silverstein foundation"},{"name":"KAMLA Research Fund of the Hebrew University of Jerusalem and Hadassah University Medical Center"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Compensatory mechanisms in Parkinson's disease (PD) are thought to explain the temporal delay between the beginning of the neurodegenerative process and the appearance of clinical signs. The enhanced structural integrity of the corticospinal tract was previously suggested as one of these mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To understand the relations between corticospinal tract integrity and the anatomical, clinical, electrophysiological, and genetic PD characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed diffusion tensor imaging (DTI) fractional anisotropy (FA) data from 40 genotyped patients with PD (18 without known genetic cause, 11 with\n                      <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                      -PD and 11 with\n                      <jats:italic toggle=\"yes\">GBA<\/jats:italic>\n                      -PD) who were candidates for subthalamic deep brain stimulation (STN-DBS) and from 25 healthy, age-matched, controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PD is associated with higher corticospinal FA values (p\u2009&lt;\u20090.001) that are negatively correlated with the disease duration (p\u2009=\u20090.032), confirming previous results. Higher FA values are negatively correlated with cerebral grey matter volumes (p\u2009&lt;\u20090.001) but not with the motor or cognitive PD characteristics, or with the subthalamic beta-oscillatory activity measured intra-operatively. Increased corticospinal FA values are strongly affected by the genetic etiology of PD, with higher values in the monogenic forms of the disease (p\u2009&lt;\u20090.001). The compensatory index, calculated by dividing the corticostriatal FA value by the cerebral grey matter volume, is highest in\n                      <jats:italic toggle=\"yes\">GBA<\/jats:italic>\n                      -PD (p\u2009&lt;\u20090.001) at the time of evaluation for STN-DBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The genetic etiology of PD strongly shapes corticospinal tract changes along with disease-duration and cerebral grey matter atrophy. The changes may serve as compensatory mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-240267","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:12:42Z","timestamp":1732612362000},"page":"1584-1593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-3740","authenticated-orcid":false,"given":"Roy","family":"Dayan","sequence":"first","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atira S","family":"Bick","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Weill","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-2659","authenticated-orcid":false,"given":"Max","family":"Bauer","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halen Baker","family":"Erdman","sequence":"additional","affiliation":[{"name":"Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-5769","authenticated-orcid":false,"given":"Zvi","family":"Israel","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-6673","authenticated-orcid":false,"given":"Hagai","family":"Bergman","sequence":"additional","affiliation":[{"name":"Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-6475","authenticated-orcid":false,"given":"Netta","family":"Levin","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1831-5310","authenticated-orcid":false,"given":"David","family":"Arkadir","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530160025009"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000243"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr233"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04639.2002"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1151775"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106137"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318253d5dd"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26167"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-4178-1"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.011"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.531993"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.020"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25558"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00654-w"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120452"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22672"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28416"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049790"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2022.862805"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29310"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep17283"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.008"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29578"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh088"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.281"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29510"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx149"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25827"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26931"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27012"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106254"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26432"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29647"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00717-y"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-240267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-240267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-240267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:07:21Z","timestamp":1780682841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-240267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.3233\/JPD-240267"],"URL":"https:\/\/doi.org\/10.3233\/jpd-240267","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]}}}