{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:29:58Z","timestamp":1780090198547,"version":"3.54.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Risk &amp; Safety in Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Angioneurotic edema is the most dangerous complication in angiotensin-converting enzyme inhibitors (ACEIs) therapy. Based on the current data, the clinical and genetic predictors of angioedema development are still understudied, which demonstrates the relevance of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To reveal the pharmacogenetic predictors of the angioedema as a secondary side effect to enalapril in patients with essential arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The study enrolled 111\u00a0subjects randomized into two groups: study group, patients with the angioedema as a secondary side effect to enalapril; and control group, patients without adverse drug reaction. All patients underwent pharmacogenetic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      An association between the development of the angioneurotic edema and the genotypes AA rs2306283 of gene\n                      <jats:italic>SLCO1B1<\/jats:italic>\n                      , TT rs4459610 of gene\n                      <jats:italic>ACE<\/jats:italic>\n                      , and CC rs1799722 of gene\n                      <jats:italic>BDKRB2<\/jats:italic>\n                      in patients was revealed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The findings justify further investigations of the revealed genetic predictors of angioedema with larger-size patient populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jrs-230006","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:43:09Z","timestamp":1695382989000},"page":"37-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacogenetic markers of development of angioneurotic edema as a secondary side effect to enalapril in patients with essential arterial hypertension"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-2651","authenticated-orcid":false,"given":"Ivan V.","family":"Sychev","sequence":"first","affiliation":[{"name":"Department of Faculty Therapy, Ogarev Mordovia State University,  Saransk, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-5941","authenticated-orcid":false,"given":"Natalia P.","family":"Denisenko","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular and Personalized Medicine,  Department of Clinical Pharmacology and Therapy named after Academician B.E. 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