{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:07:22Z","timestamp":1781021242194,"version":"3.54.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>OBJECTIVES: In premature infants with suspected intra-abdominal infection, biomarkers for treatment response to antimicrobial therapy are lacking. Intestinal fatty acid-binding protein (I-FABP) is specific to the enterocyte and is released in response to intestinal mucosal injury. I-FABP has not been evaluated as a surrogate marker of disease response to antimicrobial therapy. We examined the relationship between metronidazole exposure and urinary I-FABP concentrations in premature infants with suspected intra-abdominal infection. STUDY DESIGN: We conducted an intravenous metronidazole pharmacokinetic study, collecting \u22643 urine samples per infant for I-FABP concentration measurements. We analyzed the relationship between I-FABP concentrations and measures of metronidazole exposure and pharmacokinetics, maturational factors, and other covariates. RESULTS: Twenty-six samples from 19 premature infants were obtained during metronidazole treatment. When analyzed without regard to presence of necrotic gastrointestinal disease, there were no significant associations between predictor variables and I-FABP concentrations. However, when the sample was limited to premature infants with necrotic gastrointestinal disease, an association was found between average predicted metronidazole concentration and I-FABP concentration (p = 0.006). CONCLUSION: While a predictive association between urinary I-FABP and metronidazole systemic exposure was not observed, the data suggest the potential of this endogenous biomarker to serve as a pharmacodynamic surrogate for antimicrobial treatment of serious abdominal infections in neonates and infants.<\/jats:p>","DOI":"10.3233\/npm-1477013","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T17:14:43Z","timestamp":1575393283000},"page":"223-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Intestinal fatty-acid binding protein and metronidazole response in premature infants"],"prefix":"10.1177","volume":"7","author":[{"given":"M.R.","family":"Sampson","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.T.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Wichita Medical Research and Education Foundation, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Children's Hospital\u2013Orange County, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Capparelli","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy, University of California\u2013San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.K.","family":"Benjamin Jr.","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"Department of Pediatrics, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"Department of Pediatrics, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.L.","family":"Kearns","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pharmacology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, USA"},{"name":"Department of Pediatrics, University of Missouri\u2013Kansas City School of Medicine, Kansas City, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van den Anker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Clinical Pharmacology, Children's National Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cohen-Wolkowiez","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"Department of Pediatrics, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Best Pharmaceuticals for Children Act \u2013 Pediatric Trials Network Administrative Core Committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-1477013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-1477013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:34:32Z","timestamp":1777613672000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-1477013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.3233\/NPM-1477013"],"URL":"https:\/\/doi.org\/10.3233\/npm-1477013","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}