{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:34:47Z","timestamp":1791974087687,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2015,7,31]]},"abstract":"<jats:p>Down syndrome is the most frequent aneuploidy in live births, with an overall frequency of 1\/600-700 births. The overexpression of cystathionine \u03b2-synthase is thought to participate in the presentation of some phenotypes observed in Down syndrome.<\/jats:p>\n                  <jats:p>OBJECTIVE: The aim of this study was to compare the expression levels of cystathionine \u03b2-synthase and histopathological observations from placentas of infants with Down syndrome and healthy newborns.<\/jats:p>\n                  <jats:p>MATERIALS AND METHODS: Six placentas of fetuses\/infants with Down syndrome and sixteen placentas of healthy fetuses were studied. Cystathionine \u03b2-synthase mRNA and protein expression were performed by real-time PCR and immunohistochemistry, respectively.<\/jats:p>\n                  <jats:p>RESULTS: We observed an increase in cystathionine \u03b2-synthase mRNA expression ( p\u200a=\u200a0.0465) and protein levels ( p\u200a=\u200a0.009) in placentas of fetus\/infants with Down syndrome compared with controls. Significantly more circinate edges ( p\u200a=\u200a0.0007) and trophoblast inclusions ( p\u200a=\u200a0.0037) were observed in the group with Down syndrome compared with control group.<\/jats:p>\n                  <jats:p>CONCLUSION: The results demonstrate overexpression of cystathionine \u03b2-synthase mRNA and protein in placentas of fetuses\/infants with trisomy 21. Further histological abnormalities were found in placentas of patients with Down syndrome, suggesting an alteration in the development of placenta.<\/jats:p>","DOI":"10.3233\/npm-15814092","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T09:24:02Z","timestamp":1438853042000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of cystathionine beta-synthase and histopathological observations in placentas of patients with Down syndrome"],"prefix":"10.1177","volume":"8","author":[{"given":"J. Mart\u00ednez","family":"Pinilla","sequence":"first","affiliation":[{"name":"Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ayala-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Institute in Human Genetics, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Garc\u00eda-Robles","sequence":"additional","affiliation":[{"name":"Nutrition, Genetics and Metabolism Research Institute, Universidad el Bosque, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Olaya-C","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogota D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Institute in Human Genetics, Pontificia Universidad Javeriana, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"r1","unstructured":"HayesABatshawP1993S\u00edndrome de down [down syndrome]Clin Pediatr North Am5555569"},{"key":"r2","unstructured":"PueschelSM1981A historical viewpoint: Down syndrome growing and learning (Human potentials for children series)Kansas CityCanning, Murphy, Zaumer, Andrews and McMeel, Inc3739"},{"key":"r3","unstructured":"LopezMPMLopezPRParesVGBorgesYAValdespinoEL2000Rese\u00f1a historica del sindrome de Down [Historical review of DS]Revista ADM57193199"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1996.tb00913.x"},{"key":"r5","unstructured":"KaminkerPArmandoR2008S\u00edndrome de Down. 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