{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:01Z","timestamp":1777890301591,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2015,7,31]]},"abstract":"<jats:p>BACKGROUND: In neonatal hypoxic ischemic encephalopathy (HIE), hypo- and hyperglycemia have been associated with poor outcomes. However, glucose variability has not been reported in this population.<\/jats:p>\n                  <jats:p>OBJECTIVE: To examine the association between serum glucose variability within the first 24 hours and two-year neurodevelopmental outcomes in neonates cooled for HIE.<\/jats:p>\n                  <jats:p>STUDY DESIGN: In this retrospective cohort study, glucose, clinical and demographic data were documented from 23 term newborns treated with whole body therapeutic hypothermia. Severe neurodevelopmental outcomes from planned two-year assessments were defined as the presence of any one of the following: Gross Motor Function Classification System levels 3 to 5, Bayley III Motor Standard Score &lt;70, Bayley III Language Score &lt;70 and Bayley III Cognitive Standard Score &lt;70.<\/jats:p>\n                  <jats:p>RESULTS: The neurodevelopmental outcomes from 8 of 23 patients were considered severe, and this group demonstrated a significant increase of mean absolute glucose (MAG) change (\u20130.28 to \u20130.03, 95% CI, p\u200a=\u200a0.032). There were no significant differences between outcome groups with regards to number of patients with hyperglycemic means, one or multiple hypo- or hyperglycemic measurement(s). There were also no differences between both groups with mean glucose, although mean glucose standard deviation was approaching significance.<\/jats:p>\n                  <jats:p>CONCLUSIONS: Poor neurodevelopmental outcomes in whole body cooled HIE neonates are significantly associated with MAG changes. This information may be relevant for prognostication and potential management strategies.<\/jats:p>","DOI":"10.3233\/npm-15814107","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T09:24:28Z","timestamp":1438853068000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["High glucose variability is associated with poor neurodevelopmental outcomes in neonatal hypoxic ischemic encephalopathy"],"prefix":"10.1177","volume":"8","author":[{"given":"N.","family":"Al Shafouri","sequence":"first","affiliation":[{"name":"Section of Neonatology, Department of Pediatrics and Child Health, University of Manitoba, Children\u2019s Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Narvey","sequence":"additional","affiliation":[{"name":"Section of Neonatology, Department of Pediatrics and Child Health, University of Manitoba, Children\u2019s Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Section of Neonatology, Department of Pediatrics and Child Health, University of Manitoba, Children\u2019s Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vallance","sequence":"additional","affiliation":[{"name":"Faculty of Health Disciplines, Athabasca University, Athabasca, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Section of Pediatric Intensive Care, Department of Pediatrics and Child Health, University of Manitoba, Children\u2019s Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11812"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9404-8"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000201875.12245.6F"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1186\/cc13857"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.08.012"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1097\/JNN.0b013e31820b5f82"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.12.012"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.01.043"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0844-5"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.047"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-10"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3423"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600510"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.132484"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)01437-0"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600506"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.11.004"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4be9"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182604998"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181e88b1f"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318172d401"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1819"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818b38d2"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200608000-00006"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1186\/cc7097"},{"key":"r26","unstructured":"RodbardD2014Glycemic variability: Measurement and utility in clinical medicineand research \u2013 one viewpointDiabetes Technol Ther16611612"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-15814107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-15814107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-15814107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:03Z","timestamp":1777613703000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-15814107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,7,31]]}},"alternative-id":["10.3233\/NPM-15814107"],"URL":"https:\/\/doi.org\/10.3233\/npm-15814107","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}