{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:05:03Z","timestamp":1787025903069,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2017,10,17]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Troponin-T is a commonly used cardiac biomarker, which could be useful in perinatal asphyxia. We aimed to analyze troponin-T concentrations in asphyxiated neonates and to correlate the concentrations with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Data were collected from electronic medical records of neonates diagnosed with perinatal asphyxia over a period of four years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>There were 63 neonates with moderate to severe encephalopathy, in whom serial troponin-T concentrations had been done on days 1, 3, and 7. 53 (84%) asphyxiated infants had troponin-T concentration &gt;100\u200apg\/ml at 2\u20134\u200ah of life. The difference in troponin-T concentrations between moderate and severe encephalopathy was not statistically significant (173 vs. 263\u200apg\/ml, p value 0.40). The difference in the concentrations at 72 hours between cooled and non-cooled neonates was not significant (48.5 vs. 62.5\u200apg\/ml, p value 0.22). Troponin-T concentration was significantly higher in babies with hypotensive shock and hepatic injury, but not acute kidney injury. There was no significant correlation between troponin-T and the extent of resuscitation needed. Troponin-T concentration on day 1 of life was significantly higher in babies who died than who survived (407 vs. 168\u200apg\/ml, p value 0.03). ROC curve for troponin-T to predict mortality had an area under the curve (AUC) of 0.803; the best cut-off value (190\u200apg\/ml) had 82% sensitivity and 80% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>There was no significant difference in troponin-T concentrations between cooled and non-cooled neonates. Troponin-T concentration had a good predictive accuracy for mortality before discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-16119","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T13:38:51Z","timestamp":1503668331000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Troponin-T as a biomarker in neonates with perinatal asphyxia"],"prefix":"10.1177","volume":"10","author":[{"given":"T.","family":"Abiramalatha","sequence":"first","affiliation":[{"name":"Department of Neonatology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sudhakar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thenmozhi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.09.011"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.09.026"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0242-z"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1080\/08035250510041222"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091338"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"ref007","first-page":"243","volume":"56","author":"Simovic AM","year":"2014","journal-title":"Turk J Pediatr"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318196ee99"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31822941ee"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.07.003"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1159\/000339117"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02539.x"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.08.003"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.7.1104"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023697"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.1"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-16119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-16119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-16119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:22Z","timestamp":1777613722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-16119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,10,17]]}},"alternative-id":["10.3233\/NPM-16119"],"URL":"https:\/\/doi.org\/10.3233\/npm-16119","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}