{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:41Z","timestamp":1791434261728,"version":"4.3.3"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2017,10,17]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n \n Hypoxemic episodes commonly occur in very preterm infants and may be associated with several adverse effects. Cerebral tissue oxygen saturation (StO\n 2<\/jats:sub>\n ) as measured by near infrared spectroscopy (NIRS) may be a useful measure to assess brain oxygenation. However, knowledge on variability of StO\n 2<\/jats:sub>\n is limited in preterm infants at this time, so StO\n 2<\/jats:sub>\n dependency on arterial oxygenation (SpO\n 2<\/jats:sub>\n ) and heart rate (HR) was assessed in preterm infants using statistical methods of time series analysis.\n <\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN:<\/jats:title>\n \n StO\n 2<\/jats:sub>\n , SpO\n 2<\/jats:sub>\n , and HR were recorded from 15 preterm infants every 2 seconds for six hours. Statistical methods of time series and longitudinal data analysis were applied to the data.\n <\/jats:p>\n <\/jats:sec>\n \n RESULT:<\/jats:title>\n \n The mean StO\n 2<\/jats:sub>\n level was found as 72% (95% confidence interval (CI) 55.5% \u201385.5%) based on a moving average process with a 5 minute order. Accordingly, longitudinal SpO\n 2<\/jats:sub>\n measurements showed a mean level of 91% (95% CI 69% \u201398%). Generally, compensation strategies to cope with both StO\n 2<\/jats:sub>\n and SpO\n 2<\/jats:sub>\n desaturations were observed in the studied patients. SpO\n 2<\/jats:sub>\n had a significant effect on cerebral oxygenation ( p\u200a<\u200a0.001), but HR did not, which led to inconclusive results considering different time intervals.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n In infants with intermittent hypoxemia and bradycardia, we found a mean StO\n 2<\/jats:sub>\n level of 72% and a strong correlation with SpO\n 2<\/jats:sub>\n . We observed large differences between individuals in the ability to maintain StO\n 2<\/jats:sub>\n at a stable level.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/npm-16124","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T13:38:53Z","timestamp":1503668333000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cerebral oxygenation and desaturations in preterm infants \u2013 a longitudinal data analysis"],"prefix":"10.1177","volume":"10","author":[{"given":"Benjamin","family":"Mayer","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Ulm University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Pohl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Ulm University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut D.","family":"Hummler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Neonatology and Pediatric Intensive Care, Ulm University Medical Centre, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel B.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Clinic for Neonatology, University Hospital Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.01.046"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.01.040"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1159\/000329922"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211182"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303136"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1159\/000368294"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.85.5.0751"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/907187"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.327"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg181"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2011.07.007"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1159\/000345926"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.110"},{"issue":"5","key":"ref014","first-page":"488","volume":"103","author":"Hessel TW","year":"1992","journal-title":"ActaPaediatr"},{"key":"ref015","unstructured":"Krei\u00dfJ-P, NeuhausG. 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