{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:17Z","timestamp":1777890317544,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2017,4,11]]},"abstract":"<jats:p>INTRODUCTION: Although antifibrinolytic agents are used to prevent and treat hemorrhage, there are concerns about a potential increased risk for peripartum venous thromboembolism. We sought to determine the impact of tranexamic acid and \u025b-aminocaproic acid on in vitro clotting properties in pregnancy.<\/jats:p>\n                  <jats:p>METHODS: Blood samples were obtained from healthy pregnant, obese, and preeclamptic pregnant women ( n\u200a=\u200a10 in each group) prior to delivery as well as from healthy non-pregnant controls ( n\u200a=\u200a10). Maximum clot firmness (MCF) and clotting time (CT) were measured using rotation thromboelastometry in the presence of tranexamic acid (3, 30, or 300 \u03bcg\/mL) or \u025b-aminocaproic acid (30, 300, or 3000 \u03bcg\/mL). ANOVA and regression analyses were performed.<\/jats:p>\n                  <jats:p>RESULTS: Mean whole blood MCF was significantly higher in healthy pregnant vs. non-pregnant women (66.5 vs. 57.5\u200amm, p\u200a&lt;\u200a0.001). Among healthy pregnant women, there was no significant difference between mean MCF (whole blood alone, and with increasing tranexamic acid doses\u200a=\u200a66.5, 66.1, 66.4, 66.3\u200amm, respectively; p\u200a=\u200a0.25) or mean CT (409, 412, 420, 424\u200asec; p\u200a=\u200a0.30) after addition of tranexamic acid. Similar results were found using \u025b-aminocaproic acid. Preeclamptic women had a higher mean MCF after the addition of \u025b-aminocaproic acid and tranexamic acid ( p\u200a=\u200a0.05 and p\u200a=\u200a0.04, respectively) compared to whole blood alone.<\/jats:p>\n                  <jats:p>CONCLUSIONS: Pregnancy is a hypercoagulable state, as reflected by an increased MCF compared to non-pregnant women. Addition of antifibrinolytic therapy in vitro does not appear to increase MCF or CT for non-pregnant, pregnant, and obese women. Whether antifibrinolytics are safe in preeclampsia may require further study.<\/jats:p>","DOI":"10.3233\/npm-16139","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T10:49:10Z","timestamp":1489747750000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Using antifibrinolytics in the peripartum period \u2013 concern for a hypercoagulable effect?"],"prefix":"10.1177","volume":"10","author":[{"given":"H.K.","family":"Ahmadzia","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.L.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Pathology Clinical Services, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.J.","family":"Welsby","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Division of Cardiac Anesthesiology, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of General Pathology, Duke University Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University, Durham, NC, 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