{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:16Z","timestamp":1790801116712,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2017,4,11]]},"abstract":"<jats:p>OBJECTIVE: We aimed to investigate if endothelin 1 concentration at day 3 postnatal age could be used as a predictive marker for development of bronchopulmonary dysplasia in preterm neonates with respiratory distress syndrome.<\/jats:p>\n                  <jats:p>METHODS: This prospective observational study was done on 69 preterm neonates with gestational ages between 28 and 34 weeks and diagnosed as having respiratory distress syndrome. Serum concentrations of endothelin 1 was measured for all patients at day 3 of life and they were divided into BPD and No-BPD groups according to whether they developed bronchopulmonary dysplasia or not.<\/jats:p>\n                  <jats:p>RESULTS: A total of 17 infants were in the BPD group and 52 infants were in the No-BPD group. Serum endothelin 1 was significantly higher in the BPD group (435.39\u00b1172.88) compared with the No-BPD group (302.65\u00b149.32) ( p\u200a&lt;\u200a0.001). Serum endothelin 1 correlated significantly with days spent on mechanical ventilation ( r\u200a=\u200a0.379, p\u200a=\u200a0.022) and days spent on CPAP ( r\u200a=\u200a0.391, p\u200a=\u200a0.001). A serum endothelin 1 cut off value of 302.7\u200ang\/L could predict preterm that will develop bronchopulmonary dysplasia with a sensitivity of 88.24%, and specificity of 61.54%.<\/jats:p>\n                  <jats:p>CONCLUSION: Serum endothelin 1 is significantly increased at day 3 of life in preterm neonates with respiratory distress syndrome who later develop bronchopulmonary dysplasia (BPD). It seems to be a promising predictive marker for BPD but further studies are needed to find the appropriate time for its measurement.<\/jats:p>","DOI":"10.3233\/npm-1653","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T10:49:30Z","timestamp":1489747770000},"page":"79-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Endothelin 1 as a predictor marker for bronchopulmonary dysplasia in preterm neonates with respiratory distress syndrome"],"prefix":"10.1177","volume":"10","author":[{"given":"M.S.","family":"El Shemi","sequence":"first","affiliation":[{"name":"Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Khafagy","sequence":"additional","affiliation":[{"name":"Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Hamza","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.A.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00007"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30143-X"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00019"},{"issue":"6","key":"ref005","first-page":"631","volume":"25","author":"Merritt TA","year":"1981","journal-title":"Acta Cytol"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199711)24:5<331::AID-PPUL5>3.0.CO;2-L"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70392-0"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(03)00129-X"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00675-0"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82056-6"},{"key":"ref012","first-page":"323","volume-title":"Manual of neonatal care","author":"Bhakta KY","year":"2008","edition":"6"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.10.011"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200409000-00239"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(01)00143-8"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.05.006"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70029-6"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.4137\/BMI.S834"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2007.09.008"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00041.x"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1159\/000438979"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-1653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-1653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-1653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:46Z","timestamp":1777613746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-1653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,4,11]]}},"alternative-id":["10.3233\/NPM-1653"],"URL":"https:\/\/doi.org\/10.3233\/npm-1653","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,16]]}}}