{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:49Z","timestamp":1777890349860,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2016,6,22]]},"abstract":"<jats:p>BACKGROUND: Protein induced by vitamin K absence (PIVKA)-II, inactive precursor of prothrombin, is elevated in vitamin K (VK) deficiency. Our aims were to find the prevalence of VK deficiency in neonates, assess the utility of international normalized ratio (INR) as a screening tool, and explore the relationship between PIVKA-II, activated partial thromboplastin time (aPTT) and VK dependent anticoagulants.<\/jats:p>\n                  <jats:p>METHODS: INR, aPTT, PIVKA-II, and proteins C and S activities were measured in neonatal cord blood prior to VK administration.<\/jats:p>\n                  <jats:p>RESULTS: We found 45% of neonates had subclinical VK deficiency based on PIVKA-II levels and 7% based on INR. Receiver operating characteristic (ROC) analysis assessed the utility of INR in detecting &gt;4\u200ang\/mL of PIVKA-II and ROC of the area under the curve was 0.70 (95% CI 0.46\u20130.92, p\u200a=\u200a0.07). Proteins C and S activities were normal for age and did not correlate with PIVKA-II [(r\u200a=\u200a0.40, p\u200a=\u200a0.14) and (r\u200a=\u200a0.29, p\u200a=\u200a0.29), respectively]. There was no association between aPTT and PIVKA-II ( p\u200a=\u200a0.83).<\/jats:p>\n                  <jats:p>CONCLUSION: PIVKA-II seems to be a sensitive indicator of mild VK deficiency. Further studies are needed to investigate the lack of relationship between PIVKA-II and functional protein C or S levels.<\/jats:p>","DOI":"10.3233\/npm-16915084","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:03:21Z","timestamp":1466622201000},"page":"139-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["PIVKA-II correlates with INR but not protein C or protein S concentrations in cord blood among newborns"],"prefix":"10.1177","volume":"9","author":[{"given":"M.","family":"Teruya","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Soundar","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Hui","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Eldin","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Adcock","sequence":"additional","affiliation":[{"name":"Esoterix Coagulation, Laboratory Corporation of America Holdings, Englewood, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Teruya","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30658-0"},{"issue":"1","key":"ref002","first-page":"4","volume":"9","author":"Lippi G","year":"2011","journal-title":"Blood Transfus"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-008-0538-7"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1651.1651"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1046\/j.0141-9854.2003.00547.x"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.3_Spec_No.297"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1309\/LABNMY41RUD099J2"},{"issue":"11","key":"ref008","first-page":"817","volume":"44","author":"Chawla D","year":"2007","journal-title":"Indian Pediatr"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1117"},{"issue":"5","key":"ref010","first-page":"278","volume":"76","author":"Laosombat V","year":"1993","journal-title":"J Med Assoc Thai"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.657273"},{"issue":"1","key":"ref012","first-page":"32","volume":"11","author":"Motohara K","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.2.94"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.1.77.77"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2512"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-16915084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-16915084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-16915084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:59Z","timestamp":1777613759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-16915084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6,22]]}},"alternative-id":["10.3233\/NPM-16915084"],"URL":"https:\/\/doi.org\/10.3233\/npm-16915084","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]}}}