{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:05:02Z","timestamp":1787025902739,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2019,8,30]]},"DOI":"10.3233\/npm-180075","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:45:51Z","timestamp":1553863551000},"page":"301-312","source":"Crossref","is-referenced-by-count":26,"title":["Optimizing antibiotic use for early onset sepsis: A tertiary NICU experience"],"prefix":"10.1177","volume":"12","author":[{"given":"V.","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Strunk","sequence":"additional","affiliation":[{"name":"Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Furqan","sequence":"additional","affiliation":[{"name":"Department of Research, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Schweig","sequence":"additional","affiliation":[{"name":"Department of Research, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lefaiver","sequence":"additional","affiliation":[{"name":"Department of Research, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Prazad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Advocate Children\u2019s Hospital, Park Ridge, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"9","key":"10.3233\/NPM-180075_ref1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1055\/s-0033-1361933","article-title":"Medication use in the neonatal intensive care unit","volume":"31","author":"Hsieh","year":"2014","journal-title":"Am J Perinatol"},{"issue":"11","key":"10.3233\/NPM-180075_ref3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.ijporl.2015.09.004","article-title":"Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure","volume":"79","author":"Cross","year":"2015","journal-title":"Int J PediatrOtorhinolaryn-gol"},{"issue":"1","key":"10.3233\/NPM-180075_ref4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1542\/peds.2007-3423","article-title":"Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants","volume":"123","author":"Cotten","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"10.3233\/NPM-180075_ref5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ijo.2011.27","article-title":"Childhood overweight after establishment of the gut micro-biota: The role of delivery mode, pre-pregnancy weight and early administration of antibiotics","volume":"35","author":"Ajslev","year":"2011","journal-title":"Int J Obes (Lond)"},{"issue":"2","key":"10.3233\/NPM-180075_ref6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1183\/09031936.00105010","article-title":"Infant antibiotic use and wheeze and asthma risk: A systematic review and meta-analysis","volume":"38","author":"Penders","year":"2011","journal-title":"Eur Respir J"},{"issue":"3","key":"10.3233\/NPM-180075_ref7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/jp.2012.96","article-title":"Neonatal early-onset sepsis evaluations among well-appearing infants: Projected impact of changes in CDC GBS guidelines","volume":"33","author":"Mukhopadhyay","year":"2013","journal-title":"J Perinatol"},{"issue":"3","key":"10.3233\/NPM-180075_ref8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJM200007203430310","article-title":"Neonatal group B streptococcal disease\u2014screening and prevention","volume":"343","author":"Schuchat","year":"2000","journal-title":"N Engl J Med"},{"issue":"5","key":"10.3233\/NPM-180075_ref9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: The burden of group B Streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"issue":"1","key":"10.3233\/NPM-180075_ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.3233\/NPM-180075_ref11","doi-asserted-by":"crossref","unstructured":"Mukhopadhyay, S , Taylor JA , Von Kohorn I , Flaherman V , Burgos AE , Phillipi CA , et al. Variation in sepsis evaluation across a national network of nurseries. Pediatrics. 2017;139(3).","DOI":"10.1542\/peds.2016-2845"},{"issue":"1","key":"10.3233\/NPM-180075_ref12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.2013-1689","article-title":"Stratification of risk of early-onset sepsis in newborns >\/=34 weeks\u2019 gestation","volume":"133","author":"Escobar","year":"2014","journal-title":"Pediatrics"},{"issue":"4","key":"10.3233\/NPM-180075_ref13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/jp.2016.236","article-title":"Impact of neonatal early-onset sepsis calculator on antibiotic use within two tertiary healthcare centers","volume":"37","author":"Warren","year":"2017","journal-title":"J Perinatol"},{"issue":"4","key":"10.3233\/NPM-180075_ref14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jamapediatrics.2016.4678","article-title":"A quantitative, risk-based approach to the management of neonatal early-onset sepsis","volume":"171","author":"Kuzniewicz","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"RR-10","key":"10.3233\/NPM-180075_ref15","first-page":"1","article-title":"N.C.f.I. Division of Bacterial Diseases, C.f.D.C. Respiratory Diseases, and Prevention, Prevention of perinatal group B streptococ-cal disease\u2014revised guidelines from CDC, 2010","volume":"59","author":"Verani","year":"2010","journal-title":"MMWR RecommRep"},{"issue":"5","key":"10.3233\/NPM-180075_ref16","first-page":"1006","article-title":"Committee on Fetus and Newborn","volume":"129","author":"Polin","year":"2012","journal-title":"Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics"},{"issue":"2","key":"10.3233\/NPM-180075_ref17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-0035-1560045","article-title":"Low rate of perinatal sepsis in term infants of mothers with chorioam-nionitis","volume":"33","author":"Braun","year":"2016","journal-title":"Am J Perinatol"},{"issue":"3 Pt 1","key":"10.3233\/NPM-180075_ref18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1542\/peds.105.3.523","article-title":"Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system","volume":"105","author":"Garcia-Prats","year":"2000","journal-title":"Pediatrics"},{"issue":"3","key":"10.3233\/NPM-180075_ref19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/jgid.jgid_1_17","article-title":"Time to positivity and antibiotic sensitivity of neonatal blood cultures","volume":"9","author":"Abdelhamid","year":"2017","journal-title":"J Glob Infect Dis"},{"key":"10.3233\/NPM-180075_ref20","doi-asserted-by":"crossref","unstructured":"Shah SS , Downes KJ , Elliott MR , Bell LM , McGowan KL , Metlay JP . How long does it take to \u201crule out\u201d bacteremia in children with central venous catheters? Pediatrics. 2008;121(1):135\u201341.","DOI":"10.1542\/peds.2007-1387"},{"issue":"3","key":"10.3233\/NPM-180075_ref21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/FTD.0000000000000283","article-title":"Extended-interval dosing of gentamicin aiming for a drug-free period in neonates: A prospective cohort study","volume":"38","author":"van Maarseveen","year":"2016","journal-title":"Ther Drug Monit"},{"issue":"2","key":"10.3233\/NPM-180075_ref22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"3","key":"10.3233\/NPM-180075_ref23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/AOG.0000000000001246","article-title":"Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: Summary of a workshop","volume":"127","author":"Higgins","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.3233\/NPM-180075_ref24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1542\/hpeds.2017-0180","article-title":"Implementation of the sepsis risk calculator at an academic birth hospital","volume":"8","author":"Dhudasia","year":"2018","journal-title":"Hosp Pediatr"},{"key":"10.3233\/NPM-180075_ref25","doi-asserted-by":"crossref","unstructured":"Aghai ZH . Is early-onset sepsis risk calculator safe for the management of neonates born to mothers with chorioam-nionitis? J Perinatol. 2018.","DOI":"10.1038\/s41372-018-0069-z"},{"issue":"10","key":"10.3233\/NPM-180075_ref26","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jamapediatrics.2017.2476","article-title":"Early-onset sepsis calculator-risk of delaying treatment","volume":"171","author":"Rajbhandari","year":"2017","journal-title":"JAMA Pediatr"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-180075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:36:49Z","timestamp":1777613809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-180075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":25,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/npm-180075","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]}}}