{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:26:34Z","timestamp":1777890394897,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2020,6,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>We aimed to investigate whether the change in methemoglobin levels (\u0394MHb) predicts oxygenation response to inhaled nitric oxide (iNO) in persistent pulmonary hypertension of the newborn (PPHN) with lung disease, with or without pulmonary hypoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      In this prospective observational study, infants were categorized based on \u0394MHb and oxygenation response (\u0394PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ) following iNO: \u0394MHb \u22640 or \u0394MHb&gt;0, and \u0394PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      \u200a&lt;\u200a20\u200ammHg (Non-responder) or\u226520\u200ammHg (Responder). \u0394MHb levels were compared among infants with or without pulmonary hypoplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among infants with pulmonary hypoplasia ( n\u200a=\u200a28), \u0394MHb was not associated with an oxygenation response to iNO or survival without ECMO. Among infants without hypoplasia ( n\u200a=\u200a29), subjects with \u0394MHb&gt;0 following iNO ( n\u200a=\u200a21) had a greater \u0394PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      (median, 64\u200ammHg; IQR, 127; p\u200a&lt;\u200a0.01) and 100% survival without extracorporeal membrane oxygenation (ECMO) when compared to infants with \u0394MHb \u22640 ( n\u200a=\u200a8; median 10\u200ammHg; IQR, 33).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>PPHN secondary to lung disease without hypoplasia with increased \u0394MHb following iNO was associated with better oxygenation response and survival without ECMO compared to subjects without an increase in MHb.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-180082","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T08:21:39Z","timestamp":1573633299000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Methemoglobin and the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn"],"prefix":"10.1177","volume":"13","author":[{"given":"R.","family":"Dadiz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, John R. Oishei Children\u2019s Hospital, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.T.","family":"D\u2019Angio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA"},{"name":"University Hospitals Rainbow Babies & Children\u2019s Hospital, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lakshminrusimha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at Davis, Sacramento, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.14"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2012.11.009"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.259.6.H1921"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.2038"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210908"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181c76cdc"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.004"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.2001.0311"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.69"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.83"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.46"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1542\/peds.96.6.1153"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70124-0"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.5.e7"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.105"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20738"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01854.x"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200010000-00014"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.040"},{"key":"ref020","first-page":"CD000399","volume":"1","author":"Barrington KJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.6.838"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-180082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-180082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-180082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:36:50Z","timestamp":1777613810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-180082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6,11]]}},"alternative-id":["10.3233\/NPM-180082"],"URL":"https:\/\/doi.org\/10.3233\/npm-180082","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,11]]}}}