{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:48:05Z","timestamp":1780494485475,"version":"3.54.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2020,4,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>The purpose of this study was to describe an identified association between necrotizing enterocolitis (NEC) and prenatal opioid exposure with neonatal abstinence syndrome (NAS) in late preterm and full-term neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN:<\/jats:title>\n                    <jats:p>In this single-center retrospective cohort study, we analyzed inborn neonates with the diagnosis of NEC discharged from 2012 through 2017. We compared infants with NEC\u200a&gt;\u200a35 weeks\u2019 gestation to those with NEC&lt;35 weeks\u2019 gestation. We compared gestational age, birth weight, age of onset of symptoms, and incidence of prenatal drug exposure between groups. Significance was determined using Mann-Whitney and Fisher\u2019s exact tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Over the study period, 23 infants were identified with NEC, 9 (39%) were babies\u200a&gt;\u200a35 weeks at birth and 14 (61%)\u200a&lt;\u200a35 weeks. Those\u200a&gt;\u200a35 weeks had a higher birth weight, earlier onset of symptoms, and a higher percentage of prenatal exposure to opioids compared to those\u200a&lt;\u200a35 weeks\u2019 gestation. We further described seven infants with late gestational age onset NEC associated with prenatal opioid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In this cohort of infants with NEC discharged over a 6 year period we found a higher than expected percentage of infants born at a later gestational age. We speculate that prenatal opioid exposure might be a risk factor for NEC in neonates born at\u200a&gt;\u200a35 weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-180154","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T11:57:49Z","timestamp":1586519869000},"page":"81-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Necrotizing enterocolitis and its association with the neonatal abstinence syndrome"],"prefix":"10.1177","volume":"13","author":[{"given":"L.","family":"Andrews","sequence":"first","affiliation":[{"name":"Department of Family and Community Health at Joan C Edwards School of Medicine at Marshall University, Huntington WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.H.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Family and Community Health at Joan C Edwards School of Medicine at Marshall University, Huntington WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Haas","sequence":"additional","affiliation":[{"name":"Hoops Family Children\u2019s Hospital at Cabell Huntington Hospital, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Loudin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heyward","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Werthammer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV, 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