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We describe two cases diagnosed with extensive ischemic stroke due to carotid artery occlusion. In both cases, we demonstrated placental vasculopathy. High levels of C-reactive protein in mother and\/or neonates suggested inflammatory mechanism as a potential trigger. Both cases underwent hypothermic treatment without complications because of initial diagnosis of perinatal asphyxia. The prognosis at the time of the last follow up was severe including cerebral palsy, epilepsy and cognitive impairment. Our cases contribute to the actual debate on pathogenic mechanisms and treatment options for this rare condition.<\/jats:p>","DOI":"10.3233\/npm-1816","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T10:59:42Z","timestamp":1566298782000},"page":"479-485","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Perinatal carotid artery ischemic stroke: Report of two cases"],"prefix":"10.1177","volume":"12","author":[{"given":"A.","family":"Suppiej","sequence":"first","affiliation":[{"name":"University of Ferrara","place":["Italy"]},{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Toffoli","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Festa","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cervesi","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Manara","sequence":"additional","affiliation":[{"name":"University of Salerno","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Magarotto","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cainelli","sequence":"additional","affiliation":[{"name":"Pediatric University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0336"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973679"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01462.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00971.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.03.003"},{"key":"e_1_3_1_7_2","unstructured":"MannC. 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