{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:05:02Z","timestamp":1787025902392,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2019,6,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hypoxic ischemic encephalopathy (HIE) affects \u00a0one to two newborns per 1,000 live births and oftentimes involves multi-organ insult. The objectives were to assess the evolution of cardiac function in infants with HIE treated with therapeutic hypothermia using echocardiography (ECHO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Archived data during the period 2010-2016 was assessed. Amongst the infants with baseline ECHO assessments, a sub-cohort which had assessments in all the three phases (baseline\/pre-active cooling [T1], cooling [T2] and rewarming [T3]) was analyzed separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirty three infants formed part of the overall cohort, the gestation and birthweight were 39.6 \u00b1 1.6 weeks and 3306 \u00b1 583 g, respectively. Baseline (T1) information noted impaired cardiac performance (right ventricle stroke volume 1.08 \u00b1 0.04 ml\/kg, fractional area change [FAC] 24 \u00b1 0.5% and tricuspid annular peak systolic excursion [TAPSE] 7.46 \u00b1 0.11mm). Serial information was available for 24 of 33 infants. Cardiac function improved significantly between the cooling and the re-warming kphases. This included changes in right ventricular output (127 \u00b1 34 vs 164 \u00b1 47 ml\/kg\/min, p &lt;0.01) and FAC (20 \u00b1 3 vs 28 \u00b1 2%, p&lt;0.01). Pairwise comparisons for fractional shortening did not show significant changes. From the cooling to the rewarming phase, maximum change was noted in FAC (26.3 \u00b1 9.8%) while minimum change was noted in fractional shortening (median, interquartile range) of 4.6% (1.4, 9.1). Significant correlation between TAPSE and time to peak velocity as a proportion of right ventricular ejection time was noted (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.68, p &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In infants with moderate to severe HIE, cardiac function evolves during various phases of therapeutic hypothermia. Low output state during cooling may be due to a combination of the disease state (HIE) and cooling therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-1853","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T15:59:50Z","timestamp":1550591990000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Cardiac adaptation in asphyxiated infants treated with therapeutic hypothermia"],"prefix":"10.1177","volume":"12","author":[{"given":"A.","family":"Sehgal","sequence":"first","affiliation":[{"name":"Monash Newborn, Monash Children\u2019s Hospital, Clayton, Australia"},{"name":"Department of Pediatrics, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Linduska","sequence":"additional","affiliation":[{"name":"Monash Newborn, Monash Children\u2019s Hospital, Clayton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Monash Newborn, Monash Children\u2019s Hospital, Clayton, 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