{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:27:28Z","timestamp":1777890448515,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2020,6,11]]},"abstract":"<jats:p>Sustained fetal supraventricular tachycardia (SVT) complicated by hydrops fetalis carries a significant risk of morbidity and mortality. While there is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis, there exists significant nonrandomized experience with a number of antiarrhythmic agents that has founded the basis for management. Furthermore, recently published meta-analyses and ongoing multicenter prospective studies have aimed to bridge the gap in the literature. We report two cases of sustained fetal SVT with severe secondary hydrops fetalis managed successfully with flecainide-sotalol combination therapy in one case and sotalol-digoxin combination therapy in the second and review the literature for the management of fetal SVT.<\/jats:p>","DOI":"10.3233\/npm-190268","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T13:41:48Z","timestamp":1573220508000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sotalol as an effective adjunct therapy in the management of supraventricular tachycardia induced fetal hydrops fetalis"],"prefix":"10.1177","volume":"13","author":[{"given":"Marwan","family":"Refaat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joud","family":"El Dick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Sabra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Bitar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Tayeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Abutaqa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Arabi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40458-8"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199702000-00022"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03511.x"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3680"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026120"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1662-1"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00054-X"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.8.913"},{"key":"ref009","unstructured":"J.S. Textbook of Fetal Cardiology. \nAllanL HL SharlandG, editor. 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Amneal Pharmaceuticals LLC [cited 2019 Mar 10]. Available from: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d462d58e-fc3c-4c92-a210-e135eb1f4b77"},{"key":"ref021","unstructured":"fda.gov [internet] Betapace AF (sotalol HCl) tablets prescribing information. Bayer HealthCare Pharmaceuticals Inc [cited 2019 Mar 10]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/021151s010lbl.pdf."},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016597"},{"key":"ref023","unstructured":"clinictrials.gov [internet]. FAST Therapy Trial of Fetal Tachyarrhythmia [cited 2019 Feb 19]. 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