{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:27:29Z","timestamp":1777890449967,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>OBJECTIVE: To identify laboratory data that correlates with poor perinatal outcomes. METHODS: A retrospective chart review of women with intrahepatic cholestasis of pregnancy (ICP), admitted for delivery between January 1, 2013 and December 31, 2017, was performed. Chi-square, student\u2019s t-test, and ANOVA statistical analysis was performed. The receiver-operator characteristic curves were plotted for the prediction of each category of perinatal outcome and the areas under the curves were determined. All p-values were two-sided, and p\u200a&lt;\u200a0.05 was considered statistically significant. RESULTS: Analysis of the 61 ICP cases showed no occurrence of the intrauterine fetal demise (IUFD), stillbirth, abruption, or neonatal demise. ROC curve analysis revealed a statistically significant correlation between bile acid and AST levels and perinatal outcomes. A bile acid (BA) level equal to or greater than 37\u03bcmol\/L strongly predicted spontaneous preterm labor in women affected by ICP with a sensitivity of 100% and specificity of 60.70% (p\u200a=\u200a0.002). A BA level equal to or greater than 42\u03bcmol\/L strongly predicted meconium-stained amniotic fluid with a sensitivity of 85.70% and specificity of 66.70% (p\u200a=\u200a0.006). AST levels equal to or greater than 62 IU\/L strongly predicted NICU admission with a sensitivity of 81.30% and specificity of 62.20% (p\u200a=\u200a0.002). AST levels equal to or greater than 75 IU\/L strongly predicted hyperbilirubinemia in the neonates with a sensitivity of 87.50% and specificity of 69.80% (p\u200a=\u200a0.001). CONCLUSIONS: There is a statistically significant correlation between elevated BA and elevated AST levels and adverse perinatal outcomes.<\/jats:p>","DOI":"10.3233\/npm-190276","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T11:17:04Z","timestamp":1574767024000},"page":"513-519","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of bile acids and aspartate-aminotransferase with outcomes in cholestasis of pregnancy"],"prefix":"10.1177","volume":"13","author":[{"given":"A.L.","family":"Juusela","sequence":"first","affiliation":[{"name":"Newark Beth Israel Medical Center, Newark, NJ, 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