{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:27:31Z","timestamp":1777890451073,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The benefits of closing the ductus arteriosus in very preterm infants have not been convincingly shown in numerous clinical trials. Because a large untreated ductus arteriosus can cause death from congestive heart failure in infants born at term, we need to explain why this might not occur in premature infants born at &lt;28 weeks\u2019 gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Based on information in the literature, I have commented on the possible relationship between the pulmonary vasculature and the shunt through the patent ductus arteriosus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Many of these infants have bronchopulmonary dysplasia, in which animal and human studies have shown a reduced number of capillaries and small pulmonary arteries as well as reduction in vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1). Both of these import angiogenic factors. Some who do not have bronchopulmonary dysplasia may have a restricted pulmonary vascular bed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The increased pulmonary vascular resistance in very premature infants may restrict pulmonary blood flow even if the ductus is large, thus reducing the urgency for ductus closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-190278","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T10:24:17Z","timestamp":1602239057000},"page":"159-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction between pulmonary vasculature and the patent ductus arteriosus in very premature infants"],"prefix":"10.1177","volume":"14","author":[{"given":"Julien I.E.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.3"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951116000081"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/9781444314045"},{"key":"ref004","unstructured":"KouchoukosNT, BlackstoneEH, DotyDB, HanleyFL, KarpRB. Kirklin and Barratt-Noyes\u2019 Cardiac Surgery. Philadelphia: Churchill Livingstone; 2005."},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1939.02800080049011"},{"key":"ref006","unstructured":"FontanaRS, EdwardsJE. Congenital cardiac disease: A review of 357 cases studied pathologically. Philadelphia: Saunders; 1962."},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.02.019"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.05.006"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1068"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/thx.25.6.669"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.37.10.1014"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2101140"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9810071"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.541524"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2013.0323"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1542\/peds.75.1.80"},{"key":"ref017","unstructured":"AbmanSH. Pulmonary hypertension in chronic lung disease in infancy:pathogenesis, pathophysiology and treatment. In: Bland R, Coalson J,editors. Chronic lung disease of early infancy, Marcel Dek-ker; 1999. pp. 619-668."},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0303-8"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.043"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197609022951003"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197609022951004"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5245(02)00066-4"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.09.012"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-190278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-190278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-190278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:38:01Z","timestamp":1777613881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-190278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,9]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.3233\/NPM-190278"],"URL":"https:\/\/doi.org\/10.3233\/npm-190278","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,9]]}}}