{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:55:55Z","timestamp":1788188155407,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2020,6,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>An exclusive human milk diet (EHM) including fortification with a human milk-based fortifier has been shown to decrease the occurrence of necrotizing enterocolitis (NEC) but growth velocity may be less for infants receiving EHM compared to a bovine diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>The objective of this study was to determine if growth is improved by earlier fortification of breast milk for preterm infants supported with a human milk based fortifier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN:<\/jats:title>\n                    <jats:p>A multi-center retrospective cohort study of the outcomes of infants of 500\u2013 1250\u200ag birth weight whose breast milk feedings were fortified at &gt;60\u200amL\/kg\/day (late) versus &lt;60\u200amL\/kg\/day (early) of enteral feeding volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Median\u00b1IQR range for gestational age (27.6\u00b13.4 vs 27.0\u00b12.9 weeks, p\u200a=\u200a0.03) and chronic lung disease (CLD: 42.6 vs 27.6%, p\u200a=\u200a0.008) were higher, and weight gain (12.9\u00b12.6 vs 13.3\u00b12.6\u200ag\/kg\/day, p\u200a=\u200a0.03) was lower in the late (N\u200a=\u200a102) vs the early (N\u200a=\u200a292) group. Adjusted multiple linear regression analysis found that early fortification was associated with improved growth velocity for weight ( p\u200a=\u200a0.007) and head circumference (HC) ( p\u200a=\u200a0.021) and less negative changes in z-scores for weight ( p\u200a=\u200a0.022) and HC ( p\u200a=\u200a0.046) from birth to discharge. Adjusted multiple logistic regression found that early fortification was associated with decreased occurrence of CLD ( p\u200a=\u200a0.004). No other outcomes, including NEC, were associated with early versus late fortification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The study results suggested that early HM fortification appears to positively affect growth for infants whose human milk feedings are fortified with a human milk based fortifier without adverse effects. The incidence of CLD was also reduced in the early fortification group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-190300","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T13:41:58Z","timestamp":1573220518000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Early fortification of enteral feedings for infants &lt;1250 grams birth weight receiving a human milk diet including human milk based fortifier"],"prefix":"10.1177","volume":"13","author":[{"given":"Robert","family":"Huston","sequence":"first","affiliation":[{"name":"Northwest Newborn Specialists, PC and Pediatrix Medical Group, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lee","sequence":"additional","affiliation":[{"name":"Prolacta Bioscience, Duarte, CA, 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